C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sprouty homolog 1, antagonist of FGF signaling (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164056 SPRY1 9606 + 4:123396795-123403760 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000339241 SPRY1-002 123396801-123403752 protein_coding
  ENST00000394339 SPRY1-001 123399510-123403755 protein_coding
  ENST00000505319 SPRY1-004 123396795-123401793 protein_coding
  ENST00000507703 SPRY1-003 123398185-123402219 protein_coding
  ENST00000508849 SPRY1-006 123399968-123401696 protein_coding
  ENST00000515726 SPRY1-005 123396811-123398337 processed_transcript
  ENST00000610581 SPRY1-201 123396795-123403760 protein_coding
  ENST00000622283 SPRY1-202 123398386-123403760 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000339241ENST00000394339ENST00000505319ENST00000507703ENST00000515726ENST00000622283
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000339241 N/A N/A 1.327±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000394339 N/A N/A N/A 0.304±0.11 1.570±0.00 N/A 0.395±0.00 N/A 1.453±0.00 1.872±0.00 N/A 1.742±0.00 N/A N/A
ENST00000505319 N/A N/A N/A 0.581±0.00 N/A 1.641±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000507703 N/A N/A N/A 0.871±0.00 2.402±0.00 N/A 0.626±0.00 2.011±0.00 N/A 4.227±0.00 1.890±0.00 7.946±6.64 10.443±0.00 8.390±0.00
ENST00000515726 N/A N/A N/A N/A N/A N/A 1.161±0.00 N/A N/A 3.479±0.00 N/A N/A 9.829±0.75 N/A
ENST00000622283 79.045±0.00 18.298±0.00 N/A 0.835±0.00 18.229±13.41 60.324±0.00 7.195±0.00 3.811±1.62 0.743±0.00 30.968±0.00 6.001±1.85 7.668±4.05 10.101±2.54 15.443±9.53

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007AG CIL_0007AG_0001 CGP 4:122923074-123403760
CIL_0007V2 CIL_0007V2_0001 VISTA 4:123162273-123765299

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000132 IEA establishment of mitotic spindle orientation
GO:0001656 IEA metanephros development
GO:0001657 IEA ureteric bud development
GO:0001759 IEA organ induction
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0008285 IEA negative regulation of cell proliferation
GO:0009966 IEA regulation of signal transduction
GO:0016020 IEA membrane
GO:0034261 IEA negative regulation of Ras GTPase activity
GO:0040037 IEA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0046580 IEA negative regulation of Ras protein signal transduction
GO:0051387 IEA negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060449 IEA bud elongation involved in lung branching
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024286 spry1 sprouty homolog 1 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000037211 Spry1 sprouty homolog 1 (Drosophila) protein_coding Mus_musculus

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