C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164171 ITGA2 9606 + 5:52989326-53094779 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296585 ITGA2-001 52989326-53094779 protein_coding
  ENST00000503810 ITGA2-006 52989340-53090834 nonsense_mediated_decay
  ENST00000509814 ITGA2-004 52989440-53090653 nonsense_mediated_decay
  ENST00000509960 ITGA2-003 52989440-53090657 nonsense_mediated_decay
  ENST00000510722 ITGA2-005 52989440-53090657 nonsense_mediated_decay
  ENST00000513685 ITGA2-002 52989440-53090646 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000296585ENST00000503810ENST00000509814ENST00000509960ENST00000513685
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000296585 0.102±0.00 N/A 1.531±0.00 0.775±0.47 0.642±0.00 0.143±0.12 3.899±0.00 0.646±0.00 1.158±0.62 0.024±0.00 0.804±0.43 0.489±0.24
ENST00000503810 N/A N/A N/A N/A N/A 0.076±0.00 N/A 0.800±0.00 N/A N/A N/A N/A
ENST00000509814 N/A N/A N/A 0.974±0.00 1.888±0.00 N/A N/A N/A 1.721±0.00 N/A N/A N/A
ENST00000509960 N/A 1.041±0.00 N/A N/A N/A N/A N/A N/A 1.024±0.00 N/A N/A N/A
ENST00000513685 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.877±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007G1 CIL_0007G1_0002 CGP 5:52989326-53110063

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001618 IEA virus receptor activity
GO:0001666 IEA response to hypoxia
GO:0002687 IEA positive regulation of leukocyte migration
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005518 IMP collagen binding
GO:0005634 IEA nucleus
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0006928 IEA cellular component movement
GO:0006929 IMP substrate-dependent cell migration
GO:0006971 IEA hypotonic response
GO:0007155 IEA:TAS cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007229 IEA:IMP integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008283 IEA cell proliferation
GO:0008305 IEA:TAS integrin complex
GO:0009279 IEA cell outer membrane
GO:0009612 IEA response to mechanical stimulus
GO:0009615 IEA response to virus
GO:0009887 TAS organ morphogenesis
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010634 IEA positive regulation of epithelial cell migration
GO:0010694 IEA positive regulation of alkaline phosphatase activity
GO:0014070 IEA response to organic cyclic compound
GO:0014075 IEA response to amine
GO:0014850 IEA response to muscle activity
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0030198 TAS extracellular matrix organization
GO:0030424 IEA axon
GO:0030879 IEA mammary gland development
GO:0031346 IEA positive regulation of cell projection organization
GO:0031589 IMP cell-substrate adhesion
GO:0032403 IEA protein complex binding
GO:0032870 IEA cellular response to hormone stimulus
GO:0032967 IEA positive regulation of collagen biosynthetic process
GO:0033343 IEA positive regulation of collagen binding
GO:0033591 IEA response to L-ascorbic acid
GO:0033627 IMP cell adhesion mediated by integrin
GO:0034666 IDA integrin alpha2-beta1 complex
GO:0038064 IMP collagen receptor activity
GO:0038065 IMP collagen-activated signaling pathway
GO:0042060 IEA wound healing
GO:0042493 IEA response to drug
GO:0042995 IEA cell projection
GO:0043236 IEA laminin binding
GO:0043388 IEA positive regulation of DNA binding
GO:0043589 IEA skin morphogenesis
GO:0043679 IEA axon terminus
GO:0045178 IEA basal part of cell
GO:0045184 IEA establishment of protein localization
GO:0045727 IEA positive regulation of translation
GO:0045785 IEA positive regulation of cell adhesion
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0048333 IEP mesodermal cell differentiation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050729 IEA positive regulation of inflammatory response
GO:0050927 IEA positive regulation of positive chemotaxis
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051971 IEA positive regulation of transmission of nerve impulse
GO:0060100 IEA positive regulation of phagocytosis, engulfment
GO:0070365 IEA hepatocyte differentiation
GO:0098639 IMP collagen binding involved in cell-matrix adhesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062974 itga2.2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), duplicate 2 protein_coding Danio_rerio
ENSDARG00000086838 ITGA2 (2 of 2) integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) protein_coding Danio_rerio
ENSMUSG00000015533 Itga2 integrin alpha 2 protein_coding Mus_musculus

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