C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hes-related family bHLH transcription factor with YRPW motif 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164683 HEY1 9606 - 8:79764010-79767863 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000337919 HEY1-009 79764013-79767857 protein_coding
  ENST00000354724 HEY1-001 79764010-79767863 protein_coding
  ENST00000435063 HEY1-003 79764494-79766493 processed_transcript
  ENST00000518733 HEY1-006 79765431-79767472 protein_coding
  ENST00000519075 HEY1-005 79766934-79767760 retained_intron
  ENST00000521111 HEY1-008 79766767-79767784 retained_intron
  ENST00000523531 HEY1-007 79767010-79767857 retained_intron
  ENST00000523976 HEY1-004 79764720-79766475 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337919ENST00000354724ENST00000435063ENST00000518733ENST00000521111ENST00000523531
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337919 N/A 1.267±0.00 N/A 2.045±1.42 2.370±0.00 N/A N/A N/A N/A 1.393±0.44 N/A 0.357±0.00 1.625±0.00 N/A
ENST00000354724 13.259±0.00 3.501±0.00 N/A 7.467±3.04 3.347±0.00 2.727±2.48 3.727±3.34 2.441±0.00 0.279±0.00 4.792±0.00 3.335±3.09 2.710±2.38 8.842±2.06 6.090±2.01
ENST00000435063 N/A N/A N/A N/A 0.677±0.00 N/A N/A N/A N/A N/A 2.194±0.00 N/A 3.126±0.00 1.549±0.00
ENST00000518733 N/A N/A 1.148±0.00 N/A N/A 0.272±0.00 0.616±0.00 N/A 1.655±0.00 0.786±0.00 1.104±0.00 0.595±0.00 N/A N/A
ENST00000521111 N/A N/A N/A N/A 2.036±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000523531 N/A N/A N/A N/A N/A 0.719±0.00 0.457±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002OY CIL_0002OY_0001 CGP 8:79610814-79767863
CIL_0008LP CIL_0008LP_0001 VISTA 8:79662126-80264511
CIL_0002OV CIL_0002OV_0001 CGP 8:79764010-80030289

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000983 ISS RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988 IDA protein binding transcription factor activity
GO:0001525 IEP angiogenesis
GO:0001568 IEA blood vessel development
GO:0001570 IEA vasculogenesis
GO:0002076 IEA osteoblast development
GO:0003184 ISS pulmonary valve morphogenesis
GO:0003190 ISS atrioventricular valve formation
GO:0003198 ISS epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003199 IEA endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003203 ISS endocardial cushion morphogenesis
GO:0003208 ISS cardiac ventricle morphogenesis
GO:0003222 IEA ventricular trabecula myocardium morphogenesis
GO:0003677 IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 ISS transcription from RNA polymerase II promoter
GO:0007219 IDA Notch signaling pathway
GO:0008134 NAS transcription factor binding
GO:0009948 IEA anterior/posterior axis specification
GO:0010629 IEA negative regulation of gene expression
GO:0035912 ISS dorsal aorta morphogenesis
GO:0035939 IDA microsatellite binding
GO:0036304 ISS umbilical cord morphogenesis
GO:0043565 IEA sequence-specific DNA binding
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045746 IDA negative regulation of Notch signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0060317 ISS cardiac epithelial to mesenchymal transition
GO:0060347 ISS heart trabecula formation
GO:0060411 ISS cardiac septum morphogenesis
GO:0060412 ISS ventricular septum morphogenesis
GO:0060716 ISS labyrinthine layer blood vessel development
GO:0060840 IEA artery development
GO:0060842 ISS arterial endothelial cell differentiation
GO:0061314 IC Notch signaling involved in heart development
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:2000678 IDA negative regulation of transcription regulatory region DNA binding
GO:2000820 IDA negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212 ISS regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070538 hey1 hairy/enhancer-of-split related with YRPW motif 1 protein_coding Danio_rerio
ENSMUSG00000040289 Hey1 hairy/enhancer-of-split related with YRPW motif 1 protein_coding Mus_musculus

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