C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: spleen tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165025 SYK 9606 + 9:90801787-90898549 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000375746 SYK-002 90827488-90898549 protein_coding
  ENST00000375747 SYK-003 90801927-90898549 protein_coding
  ENST00000375751 SYK-004 90801787-90898549 protein_coding
  ENST00000375754 SYK-001 90801787-90898549 protein_coding
  ENST00000476708 SYK-005 90801962-90844246 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375747ENST00000375751ENST00000375754ENST00000476708
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375747 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.221±1.81 3.076±0.00 1.609±0.00
ENST00000375751 N/A N/A 0.222±0.00 N/A N/A 2.116±0.00 N/A 4.812±0.00 N/A 1.859±0.00 0.151±0.00 1.196±0.62 2.390±0.60 0.973±0.00
ENST00000375754 2.969±0.00 9.495±0.00 N/A 1.715±0.00 1.230±0.17 2.028±0.18 0.581±0.16 2.292±0.00 0.593±0.19 1.173±0.50 N/A 1.535±0.65 5.179±1.16 1.634±1.13
ENST00000476708 N/A N/A N/A N/A N/A N/A N/A 6.035±0.00 N/A N/A 0.610±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002JT CIL_0002JT_0001 CGP 9:90609832-90898549
CIL_0002JN CIL_0002JN_0001 CGP 9:90801787-91361913

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0001820 IEA serotonin secretion
GO:0001945 ISS lymph vessel development
GO:0002250 ISS adaptive immune response
GO:0002281 ISS macrophage activation involved in immune response
GO:0002283 ISS neutrophil activation involved in immune response
GO:0002366 ISS leukocyte activation involved in immune response
GO:0002554 ISS serotonin secretion by platelet
GO:0004672 NAS:IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 IDA:IEA non-membrane spanning protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005829 IC cytosol
GO:0005886 TAS plasma membrane
GO:0006468 ISS:IEA protein phosphorylation
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007167 IEA enzyme linked receptor protein signaling pathway
GO:0007229 ISS integrin-mediated signaling pathway
GO:0007257 IEA activation of JUN kinase activity
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0009887 TAS organ morphogenesis
GO:0010543 ISS regulation of platelet activation
GO:0016032 IEA viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019370 IEA leukotriene biosynthetic process
GO:0019815 IEA B cell receptor complex
GO:0019901 IEA protein kinase binding
GO:0030168 TAS platelet activation
GO:0030593 IDA neutrophil chemotaxis
GO:0032009 ISS early phagosome
GO:0032928 ISS regulation of superoxide anion generation
GO:0033630 ISS positive regulation of cell adhesion mediated by integrin
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042101 IDA T cell receptor complex
GO:0042742 ISS defense response to bacterium
GO:0043234 IEA protein complex
GO:0043306 IEA positive regulation of mast cell degranulation
GO:0043313 ISS regulation of neutrophil degranulation
GO:0043366 IEA beta selection
GO:0045087 ISS innate immune response
GO:0045401 IEA positive regulation of interleukin-3 biosynthetic process
GO:0045425 IEA positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045579 IEA positive regulation of B cell differentiation
GO:0045588 IEA positive regulation of gamma-delta T cell differentiation
GO:0045780 ISS positive regulation of bone resorption
GO:0046638 IEA positive regulation of alpha-beta T cell differentiation
GO:0046641 IEA positive regulation of alpha-beta T cell proliferation
GO:0046777 IEA protein autophosphorylation
GO:0048514 ISS blood vessel morphogenesis
GO:0050715 IEA positive regulation of cytokine secretion
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 ISS regulation of phagocytosis
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0050853 ISS B cell receptor signaling pathway
GO:0070372 ISS regulation of ERK1 and ERK2 cascade
GO:0071226 ISS cellular response to molecule of fungal origin
GO:0090237 ISS regulation of arachidonic acid secretion
GO:0090330 ISS regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008186 syk spleen tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000021457 Syk spleen tyrosine kinase protein_coding Mus_musculus

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