C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: spleen tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021457 Syk 10090 + 13:52583173-52648792 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000055087 Syk-002 52596853-52648782 protein_coding
  ENSMUST00000118756 Syk-003 52583437-52643614 protein_coding
  ENSMUST00000120135 Syk-001 52583173-52648792 protein_coding
  ENSMUST00000140339 Syk-005 52596959-52624339 retained_intron
  ENSMUST00000150672 Syk-004 52583503-52613685 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000055087ENSMUST00000120135ENSMUST00000140339
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000055087 1.760±0.84 0.753±0.20 1.074±0.40 0.505±0.04 7.394±3.95 N/A 1.466±0.36 0.716±0.32 1.205±0.64 2.721±0.43 0.546±0.07 2.134±1.65 1.413±1.02 0.193±0.04
ENSMUST00000120135 2.615±0.75 0.980±0.32 0.847±0.30 0.241±0.08 7.587±3.21 8.137±3.67 1.969±0.66 0.750±0.11 1.904±1.06 5.081±1.10 0.630±0.20 1.947±0.76 0.993±1.00 0.125±0.04
ENSMUST00000140339 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.592±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002JT CIL_0002JT_0002 CGP 13:52504375-52648792
CIL_0002JN CIL_0002JN_0002 CGP 13:52583173-52929681

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0001820 IMP serotonin secretion
GO:0001945 IMP lymph vessel development
GO:0002250 ISS adaptive immune response
GO:0002281 IMP macrophage activation involved in immune response
GO:0002283 IMP neutrophil activation involved in immune response
GO:0002366 IMP leukocyte activation involved in immune response
GO:0002554 IMP serotonin secretion by platelet
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004716 IDA receptor signaling protein tyrosine kinase activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 ISS protein phosphorylation
GO:0007159 ISS leukocyte cell-cell adhesion
GO:0007166 IMP cell surface receptor signaling pathway
GO:0007167 IDA enzyme linked receptor protein signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007257 IMP activation of JUN kinase activity
GO:0010543 IMP regulation of platelet activation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019370 IMP leukotriene biosynthetic process
GO:0019815 IDA B cell receptor complex
GO:0019901 IPI protein kinase binding
GO:0030593 ISS neutrophil chemotaxis
GO:0032009 IDA early phagosome
GO:0032928 IMP regulation of superoxide anion generation
GO:0033630 IMP positive regulation of cell adhesion mediated by integrin
GO:0035556 IDA intracellular signal transduction
GO:0042101 IEA T cell receptor complex
GO:0042742 IMP defense response to bacterium
GO:0043234 IDA protein complex
GO:0043306 IMP positive regulation of mast cell degranulation
GO:0043313 IMP regulation of neutrophil degranulation
GO:0043366 IGI beta selection
GO:0045087 IMP innate immune response
GO:0045401 IMP positive regulation of interleukin-3 biosynthetic process
GO:0045425 IMP positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045579 IMP positive regulation of B cell differentiation
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0045780 IMP positive regulation of bone resorption
GO:0046638 IGI positive regulation of alpha-beta T cell differentiation
GO:0046641 IGI positive regulation of alpha-beta T cell proliferation
GO:0046777 IDA protein autophosphorylation
GO:0048514 IMP blood vessel morphogenesis
GO:0050715 IGI positive regulation of cytokine secretion
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 IMP regulation of phagocytosis
GO:0050850 IMP positive regulation of calcium-mediated signaling
GO:0050853 IDA B cell receptor signaling pathway
GO:0070372 IMP regulation of ERK1 and ERK2 cascade
GO:0071226 IMP cellular response to molecule of fungal origin
GO:0090237 IMP regulation of arachidonic acid secretion
GO:0090330 IMP regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008186 syk spleen tyrosine kinase protein_coding Danio_rerio
ENSG00000165025 SYK spleen tyrosine kinase protein_coding Homo_sapiens

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