C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165406 MARCH8 9606 - 10:45454585-45594906 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000319836 MARCH8-201 45454593-45594906 protein_coding
  ENST00000395769 MARCH8-001 45457506-45535371 protein_coding
  ENST00000451376 MARCH8-006 45593430-45594598 processed_transcript
  ENST00000453424 MARCH8-002 45454585-45535394 protein_coding
  ENST00000453980 MARCH8-004 45461387-45594491 protein_coding
  ENST00000476962 MARCH8-003 45457511-45462204 processed_transcript
  ENST00000602712 MARCH8-005 45461083-45594577 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000319836ENST00000395769ENST00000453424ENST00000453980ENST00000476962ENST00000602712
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000319836 7.683±0.00 9.296±0.00 1.502±0.00 2.414±0.00 5.144±2.89 3.313±1.05 5.893±4.30 4.122±0.56 2.353±1.69 2.803±2.18 3.005±0.00 3.354±2.18 3.632±1.59 9.111±2.13
ENST00000395769 N/A N/A 1.912±0.00 N/A 2.152±0.00 2.291±0.00 1.416±0.00 N/A N/A 2.395±0.00 N/A N/A N/A 6.071±0.00
ENST00000453424 N/A N/A 0.605±0.00 N/A N/A 0.993±0.00 N/A 0.883±0.00 0.635±0.00 0.978±0.15 N/A 0.593±0.21 0.770±0.00 5.880±2.77
ENST00000453980 N/A N/A N/A N/A N/A N/A N/A N/A 4.594±0.00 3.454±0.00 N/A N/A N/A N/A
ENST00000476962 N/A N/A N/A N/A N/A N/A N/A N/A 1.336±0.00 N/A N/A N/A N/A N/A
ENST00000602712 N/A N/A N/A N/A N/A 6.539±0.00 N/A 5.759±0.00 3.085±0.00 2.154±0.00 N/A 3.773±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081B CIL_00081B_0001 VISTA 10:45257434-45860222
CIL_0000X4 CIL_0000X4_0002 CGP 10:45454585-45672780

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0002376 IEA immune system process
GO:0002495 IEA antigen processing and presentation of peptide antigen via MHC class II
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IEA protein binding
GO:0005764 IDA lysosome
GO:0005768 IDA endosome
GO:0008270 IEA zinc ion binding
GO:0016021 IEA integral component of membrane
GO:0016874 IEA ligase activity
GO:0031410 IEA cytoplasmic vesicle
GO:0042289 IEA MHC class II protein binding
GO:0045347 IEA negative regulation of MHC class II biosynthetic process
GO:0046872 IEA metal ion binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062489 march8 membrane-associated ring finger (C3HC4) 8 protein_coding Danio_rerio
ENSMUSG00000025702 March8 membrane-associated ring finger (C3HC4) 8 protein_coding Mus_musculus

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