C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methyltransferase like 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165819 METTL3 9606 - 14:21498133-21511375 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000298717 METTL3-001 21498138-21511375 protein_coding
  ENST00000367606 METTL3-014 21507651-21511340 processed_transcript
  ENST00000377543 METTL3-016 21503404-21509554 protein_coding
  ENST00000396522 METTL3-008 21498146-21504942 retained_intron
  ENST00000536201 METTL3-002 21501152-21511340 retained_intron
  ENST00000537163 METTL3-003 21498162-21511340 nonsense_mediated_decay
  ENST00000538267 METTL3-007 21502379-21511259 retained_intron
  ENST00000539760 METTL3-010 21498133-21503829 nonsense_mediated_decay
  ENST00000542054 METTL3-011 21501690-21511340 retained_intron
  ENST00000543235 METTL3-006 21498173-21511310 nonsense_mediated_decay
  ENST00000544248 METTL3-004 21499025-21511338 nonsense_mediated_decay
  ENST00000544500 METTL3-009 21498146-21503829 retained_intron
  ENST00000545319 METTL3-013 21510568-21511340 processed_transcript
  ENST00000545788 METTL3-012 21510655-21511342 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000298717ENST00000537163ENST00000543235ENST00000544500
Transcript ID Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000298717 N/A N/A 5.535±0.00 4.729±1.82 8.559±4.23 3.890±0.00 10.045±0.00 N/A 9.519±4.08 12.352±1.60 21.781±0.00
ENST00000537163 1.947±0.00 N/A 5.438±0.00 N/A N/A N/A N/A N/A 7.319±0.00 N/A 16.736±0.00
ENST00000543235 N/A 5.340±0.00 N/A N/A N/A 3.055±0.00 N/A 2.496±0.00 N/A N/A N/A
ENST00000544500 2.148±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CX CIL_0008CX_0001 VISTA 14:21403052-22005074
CIL_0005QL CIL_0005QL_0001 CGP 14:21459020-21499175
CIL_0002HL CIL_0002HL_0001 CGP 14:21476597-21511375
CIL_0002HK CIL_0002HK_0001 CGP 14:21498133-21537216

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001510 IMP RNA methylation
GO:0003723 IEA RNA binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006139 IEA nucleobase-containing compound metabolic process
GO:0006397 ISS mRNA processing
GO:0007623 ISS circadian rhythm
GO:0008168 IEA methyltransferase activity
GO:0010467 TAS gene expression
GO:0016422 IMP mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0016607 IDA nuclear speck
GO:0019827 ISS stem cell maintenance
GO:0032259 IEA methylation
GO:0036396 IDA MIS complex
GO:0061157 ISS mRNA destabilization
GO:0080009 IMP mRNA methylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012827 mettl3 methyltransferase like 3 protein_coding Danio_rerio
ENSMUSG00000022160 Mettl3 methyltransferase like 3 protein_coding Mus_musculus

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