C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, ATPase, 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165916 PSMC3 9606 - 11:47418769-47426473 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000298852 PSMC3-001 47418769-47426437 protein_coding
  ENST00000524447 PSMC3-011 47420339-47426225 protein_coding
  ENST00000526993 PSMC3-004 47424108-47426258 protein_coding
  ENST00000527906 PSMC3-006 47422933-47426255 nonsense_mediated_decay
  ENST00000528362 PSMC3-008 47424423-47426251 retained_intron
  ENST00000529500 PSMC3-003 47425439-47426255 retained_intron
  ENST00000530651 PSMC3-005 47422574-47426216 protein_coding
  ENST00000530887 PSMC3-007 47422574-47426198 nonsense_mediated_decay
  ENST00000530912 PSMC3-002 47418802-47426442 protein_coding
  ENST00000531051 PSMC3-010 47422574-47426235 protein_coding
  ENST00000531653 PSMC3-009 47424364-47426259 retained_intron
  ENST00000602866 PSMC3-012 47418769-47426266 protein_coding
  ENST00000619920 PSMC3-201 47418769-47426473 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000298852ENST00000524447ENST00000527906ENST00000530651ENST00000531051ENST00000531653ENST00000602866ENST00000619920
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000298852 N/A N/A 3.475±0.00 3.833±0.00 2.852±0.00 1.854±0.00 1.306±0.00 10.338±0.00 6.753±4.48 N/A 10.451±3.79 8.901±0.00 17.306±0.00 12.117±0.00
ENST00000524447 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.407±0.00 4.589±1.54 N/A 8.198±0.00
ENST00000527906 N/A N/A 2.547±0.00 6.020±0.00 4.603±0.00 N/A 2.917±0.00 8.074±0.00 3.827±0.00 3.196±0.00 N/A 1.957±0.00 N/A N/A
ENST00000530651 N/A N/A N/A N/A N/A 2.652±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000531051 15.242±0.00 N/A N/A N/A 21.166±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000531653 N/A N/A 2.814±0.00 N/A N/A N/A N/A N/A 6.758±0.00 N/A N/A N/A N/A N/A
ENST00000602866 48.886±0.00 66.008±0.00 N/A 26.347±16.83 30.999±23.47 42.373±36.09 29.399±21.10 29.603±19.87 23.316±19.58 29.092±25.74 58.644±46.32 33.902±23.83 94.595±37.20 38.343±17.34
ENST00000619920 8.932±0.00 N/A N/A 8.329±4.74 N/A N/A N/A N/A 1.393±0.00 2.555±0.00 N/A 2.164±0.00 9.003±0.00 16.409±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0000932 ISS cytoplasmic mRNA processing body
GO:0001824 IEA blastocyst development
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0003713 TAS transcription coactivator activity
GO:0003714 TAS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006200 ISS ATP catabolic process
GO:0006281 IEA DNA repair
GO:0006310 IEA DNA recombination
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0009378 IEA four-way junction helicase activity
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016787 IEA hydrolase activity
GO:0016887 ISS:IEA ATPase activity
GO:0022624 ISS proteasome accessory complex
GO:0030163 IEA protein catabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:2001141 TAS regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007141 psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 protein_coding Danio_rerio
ENSMUSG00000002102 Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 protein_coding Mus_musculus

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