C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: HtrA serine peptidase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166033 HTRA1 9606 + 10:122461525-122514908 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368984 HTRA1-001 122461525-122514908 protein_coding
  ENST00000420892 HTRA1-002 122506691-122514907 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368984ENST00000420892
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368984 44.916±0.00 31.100±0.00 3.721±0.00 74.665±51.21 48.950±35.86 24.922±21.39 12.091±7.53 29.510±21.88 51.495±39.77 16.525±11.54 6.258±2.20 111.169±98.60 239.569±80.54 23.179±15.40
ENST00000420892 48.770±0.00 49.299±0.00 2.845±0.00 62.999±30.22 61.725±57.58 32.688±30.04 8.664±0.00 17.417±14.41 52.963±48.45 11.652±0.00 7.700±0.00 140.903±124.45 261.741±107.33 48.465±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000QM CIL_0000QM_0001 CGP 10:122461525-122643736

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 IEA regulation of cell growth
GO:0003824 IEA catalytic activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IEA protein binding
GO:0005520 IEA insulin-like growth factor binding
GO:0005576 IEA extracellular region
GO:0005615 TAS extracellular space
GO:0005737 IEA cytoplasm
GO:0006508 ISS:IEA proteolysis
GO:0008236 ISS serine-type peptidase activity
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0031012 IDA extracellular matrix
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050687 IEA negative regulation of defense response to virus
GO:0070062 IDA extracellular vesicular exosome
GO:0097187 IEA dentinogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014907 htra1b HtrA serine peptidase 1b protein_coding Danio_rerio
ENSDARG00000032831 htra1a HtrA serine peptidase 1a protein_coding Danio_rerio
ENSMUSG00000006205 Htra1 HtrA serine peptidase 1 protein_coding Mus_musculus

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