C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: beta-transducin repeat containing E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166167 BTRC 9606 + 10:101354033-101557321 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000370183 BTRC-005 101354534-101526083 protein_coding
  ENST00000370187 BTRC-001 101354063-101557321 protein_coding
  ENST00000393441 BTRC-201 101354033-101557319 protein_coding
  ENST00000408038 BTRC-002 101354107-101557321 protein_coding
  ENST00000465182 BTRC-006 101354182-101526194 processed_transcript
  ENST00000475200 BTRC-004 101354069-101521712 processed_transcript
  ENST00000493877 BTRC-003 101535384-101551191 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000370187ENST00000393441ENST00000408038ENST00000475200
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000370187 2.185±0.00 N/A N/A 7.173±3.82 N/A 0.873±0.13 2.830±1.99 1.786±0.48 1.249±0.27 N/A 2.425±0.00 3.517±1.50 0.876±0.34 4.323±0.69
ENST00000393441 N/A 0.568±0.00 1.028±0.00 4.712±0.00 N/A 0.988±0.00 N/A 1.404±0.00 0.685±0.00 N/A N/A 1.080±0.01 0.725±0.00 1.416±0.00
ENST00000408038 N/A 1.733±0.00 N/A 0.945±0.00 1.852±0.08 N/A N/A N/A N/A 1.274±0.12 N/A 0.936±0.21 1.194±0.00 1.591±0.00
ENST00000475200 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.684±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000940 CIL_000940_0001 VISTA 10:100919065-101519843
CIL_0007ZR CIL_0007ZR_0001 VISTA 10:101034855-101635629
CIL_00089J CIL_00089J_0001 VISTA 10:101185253-101786853
CIL_000942 CIL_000942_0001 VISTA 10:101206892-101808215
CIL_0007PC CIL_0007PC_0001 UCNEbase 10:101219422-101507851
CIL_0005NA CIL_0005NA_0001 CGP 10:101226195-101557321

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000209 IEA protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006470 ISS protein dephosphorylation
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0007165 TAS signal transduction
GO:0008013 IEA beta-catenin binding
GO:0016032 TAS viral process
GO:0016055 IEA Wnt signaling pathway
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019005 IDA SCF ubiquitin ligase complex
GO:0030163 IEA protein catabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146 IBA SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648 IMP protein destabilization
GO:0033598 IEA mammary gland epithelial cell proliferation
GO:0042752 IDA regulation of circadian rhythm
GO:0042753 ISS positive regulation of circadian rhythm
GO:0043122 IEA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 TAS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045309 IEA protein phosphorylated amino acid binding
GO:0045862 IMP positive regulation of proteolysis
GO:0045879 TAS negative regulation of smoothened signaling pathway
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046983 IEA protein dimerization activity
GO:0048511 IEA rhythmic process
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051726 IEA regulation of cell cycle
GO:0060444 IEA branching involved in mammary gland duct morphogenesis
GO:0061136 IEA regulation of proteasomal protein catabolic process
GO:0071407 IEA cellular response to organic cyclic compound

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000025217 Btrc beta-transducin repeat containing protein protein_coding Mus_musculus

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