C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific methyltransferase 2D
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167548 KMT2D 9606 - 12:49018975-49059774 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000301067 KMT2D-001 49018975-49055324 protein_coding
  ENST00000526209 KMT2D-002 49021578-49024624 protein_coding
  ENST00000547610 KMT2D-007 49054380-49059774 protein_coding
  ENST00000549743 KMT2D-005 49035575-49037296 processed_transcript
  ENST00000549799 KMT2D-006 49038468-49039299 processed_transcript
  ENST00000550356 KMT2D-003 49043078-49043698 retained_intron
  ENST00000552391 KMT2D-004 49030280-49031404 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000301067ENST00000526209
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000301067 5.611±0.00 6.739±0.00 0.662±0.00 2.415±0.93 4.015±0.00 3.010±0.00 2.475±1.55 1.731±0.53 1.841±0.47 4.068±2.66 4.821±3.73 5.385±2.24 3.873±0.60 5.540±0.86
ENST00000526209 N/A N/A N/A N/A N/A N/A N/A 5.945±0.00 N/A N/A N/A 31.300±0.00 26.097±0.00 21.010±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00000E CIL_00000E_0001 CGP 12:48995149-49019197
CIL_00000J CIL_00000J_0001 CGP 12:49002274-49059774
CIL_00003S CIL_00003S_0001 CGP 12:49018975-49070025

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001555 ISS oocyte growth
GO:0003677 NAS DNA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 NAS:IEA nucleus
GO:0006342 ISS chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0008168 IEA methyltransferase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0032259 IEA methylation
GO:0033148 IMP positive regulation of intracellular estrogen receptor signaling pathway
GO:0035097 IPI histone methyltransferase complex
GO:0043627 IDA response to estrogen
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048477 ISS oogenesis
GO:0051568 ISS histone H3-K4 methylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037060 kmt2d lysine (K)-specific methyltransferase 2D protein_coding Danio_rerio
ENSMUSG00000048154 Kmt2d lysine (K)-specific methyltransferase 2D protein_coding Mus_musculus

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