C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lysine (K)-specific methyltransferase 2D
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000301067 KMT2D-001 ENSG00000167548 9606 - 12:49018975-49055324 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000301067
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000301067 5.611±0.00 6.739±0.00 0.662±0.00 2.415±0.93 4.015±0.00 3.010±0.00 2.475±1.55 1.731±0.53 1.841±0.47 4.068±2.66 4.821±3.73 5.385±2.24 3.873±0.60 5.540±0.86

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00000E CIL_00000E_0001 CGP 12:48995149-49019197
CIL_00000J CIL_00000J_0001 CGP 12:49002274-49059774
CIL_00003S CIL_00003S_0001 CGP 12:49018975-49070025

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001555 ISS oocyte growth
GO:0003677 NAS DNA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 NAS:IEA nucleus
GO:0006342 ISS chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0008270 IEA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0033148 IMP positive regulation of intracellular estrogen receptor signaling pathway
GO:0035097 IPI histone methyltransferase complex
GO:0043627 IDA response to estrogen
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048477 ISS oogenesis
GO:0051568 ISS histone H3-K4 methylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000178486 Kmt2d-201 protein_coding Mus_musculus 0 7993
ENSMUST00000023741 Kmt2d-001 protein_coding Mus_musculus 0 7993
ENSDART00000137010 kmt2ca-001 protein_coding Danio_rerio 2e-36 161
ENSDART00000112279 kmt2cb-201 protein_coding Danio_rerio 1e-18 102
ENSDART00000131780 kmt2cb-001 protein_coding Danio_rerio 1e-18 102

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