C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: microtubule crosslinking factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168502 MTCL1 9606 + 18:8705661-8832778 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306329 MTCL1-015 8705661-8828946 protein_coding
  ENST00000359865 MTCL1-001 8717371-8832778 protein_coding
  ENST00000400050 MTCL1-201 8717898-8832777 protein_coding
  ENST00000517554 MTCL1-005 8784658-8787303 retained_intron
  ENST00000517570 MTCL1-003 8707411-8832777 protein_coding
  ENST00000518226 MTCL1-012 8809818-8813157 processed_transcript
  ENST00000518815 MTCL1-006 8789674-8832778 protein_coding
  ENST00000519823 MTCL1-017 8811131-8819245 processed_transcript
  ENST00000520495 MTCL1-004 8782088-8810002 nonsense_mediated_decay
  ENST00000520926 MTCL1-013 8812845-8819171 retained_intron
  ENST00000521018 MTCL1-010 8784674-8787344 processed_transcript
  ENST00000522146 MTCL1-008 8717376-8777977 retained_intron
  ENST00000522592 MTCL1-011 8800442-8813044 processed_transcript
  ENST00000523122 MTCL1-007 8717759-8718592 protein_coding
  ENST00000523811 MTCL1-009 8784541-8785860 processed_transcript
  ENST00000581670 MTCL1-016 8829923-8832778 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306329ENST00000400050ENST00000517554ENST00000517570ENST00000518815ENST00000520926ENST00000521018ENST00000522146ENST00000581670
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306329 0.309±0.00 0.090±0.00 0.615±0.00 0.273±0.19 N/A 0.110±0.00 0.410±0.00 0.871±0.00 0.264±0.00 0.121±0.00 2.345±1.75 0.529±0.27 2.877±0.00
ENST00000400050 0.127±0.00 N/A 1.394±0.00 0.206±0.00 0.864±0.00 N/A N/A 0.947±0.00 0.030±0.00 0.188±0.00 N/A N/A N/A
ENST00000517554 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.176±0.00 N/A N/A N/A
ENST00000517570 N/A N/A 3.080±0.00 0.084±0.00 2.709±0.00 N/A N/A 0.170±0.00 N/A N/A 0.572±0.13 0.699±0.41 N/A
ENST00000518815 0.221±0.00 N/A N/A N/A N/A N/A 0.596±0.00 N/A 0.048±0.00 N/A 1.601±1.13 0.427±0.00 2.246±0.03
ENST00000520926 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.237±0.00 7.308±0.00
ENST00000521018 N/A N/A N/A N/A N/A N/A 0.863±0.00 N/A N/A N/A N/A N/A N/A
ENST00000522146 N/A N/A 13.298±0.00 3.948±0.00 5.155±0.00 0.522±0.00 0.832±0.00 N/A 0.354±0.00 1.404±0.00 10.096±0.00 2.096±0.00 N/A
ENST00000581670 N/A N/A 1.384±0.00 N/A 1.279±0.00 0.079±0.00 0.333±0.00 0.143±0.00 N/A N/A 1.960±2.22 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00025R CIL_00025R_0002 CGP 18:8609445-8832778

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000922 IDA spindle pole
GO:0001578 ISS microtubule bundle formation
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0005856 IDA cytoskeleton
GO:0008017 IDA microtubule binding
GO:0010506 IEA regulation of autophagy
GO:0016327 ISS apicolateral plasma membrane
GO:0016328 ISS lateral plasma membrane
GO:0030496 IDA midbody
GO:0042803 ISS protein homodimerization activity
GO:0044822 IDA poly(A) RNA binding
GO:0045197 ISS establishment or maintenance of epithelial cell apical/basal polarity
GO:0090314 ISS positive regulation of protein targeting to membrane
GO:0097427 ISS microtubule bundle
GO:2000576 ISS positive regulation of microtubule motor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091408 MTCL1 (2 of 2) microtubule crosslinking factor 1 protein_coding Danio_rerio
ENSMUSG00000052105 Mtcl1 microtubule crosslinking factor 1 protein_coding Mus_musculus

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