C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tet methylcytosine dioxygenase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168769 TET2 9606 + 4:105145875-105279816 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265149 TET2-005 105146786-105279803 nonsense_mediated_decay
  ENST00000305737 TET2-001 105145875-105242771 protein_coding
  ENST00000380013 TET2-002 105146786-105279803 protein_coding
  ENST00000394764 TET2-201 105146923-105242762 protein_coding
  ENST00000413648 TET2-004 105146886-105242762 protein_coding
  ENST00000504042 TET2-007 105146878-105202546 processed_transcript
  ENST00000505801 TET2-008 105146933-105190703 retained_intron
  ENST00000513237 TET2-003 105146293-105279816 protein_coding
  ENST00000514870 TET2-006 105147457-105234272 protein_coding
  ENST00000540549 TET2-202 105146293-105279816 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265149ENST00000305737ENST00000380013ENST00000394764ENST00000513237
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265149 0.511±0.00 0.530±0.00 0.487±0.00 0.539±0.00 1.262±0.90 0.221±0.00 0.455±0.00 0.130±0.00 0.853±0.00 0.416±0.00 0.353±0.04 0.228±0.00 N/A
ENST00000305737 0.513±0.00 0.261±0.00 N/A 0.828±0.00 0.481±0.22 0.657±0.00 N/A N/A N/A N/A 0.209±0.00 N/A 0.286±0.00
ENST00000380013 N/A 0.219±0.00 0.699±0.37 1.439±0.81 0.138±0.00 0.750±0.13 1.263±0.00 0.292±0.00 2.611±0.00 0.554±0.00 0.766±0.55 0.776±0.00 0.541±0.33
ENST00000394764 N/A N/A 0.300±0.00 N/A N/A N/A N/A N/A 1.604±0.08 0.541±0.27 N/A N/A N/A
ENST00000513237 N/A 0.258±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.617±0.20 0.415±0.23 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00002E CIL_00002E_0002 CGP 4:104468312-105279816
CIL_0006P2 CIL_0006P2_0002 CGP 4:105145875-105474081

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IEA kidney development
GO:0002318 IEA myeloid progenitor cell differentiation
GO:0003677 IEA DNA binding
GO:0005515 IPI protein binding
GO:0006211 IDA 5-methylcytosine catabolic process
GO:0006493 IDA protein O-linked glycosylation
GO:0007049 IEA cell cycle
GO:0008198 IDA ferrous iron binding
GO:0008270 IDA zinc ion binding
GO:0009791 IEA post-embryonic development
GO:0019857 IEA 5-methylcytosine metabolic process
GO:0019858 IEA cytosine metabolic process
GO:0020027 IEA hemoglobin metabolic process
GO:0030097 IEA hemopoiesis
GO:0030099 IMP myeloid cell differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048536 IEA spleen development
GO:0048872 IEA homeostasis of number of cells
GO:0055114 IEA oxidation-reduction process
GO:0061484 IEA hematopoietic stem cell homeostasis
GO:0070579 ISS methylcytosine dioxygenase activity
GO:0072576 IEA liver morphogenesis
GO:0080111 IDA DNA demethylation
GO:0080182 IMP histone H3-K4 trimethylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076928 tet2 tet methylcytosine dioxygenase 2 protein_coding Danio_rerio
ENSMUSG00000040943 Tet2 tet methylcytosine dioxygenase 2 protein_coding Mus_musculus

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