C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169188 APEX2 9606 + X:55000357-55009057 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374987 APEX2-001 55000357-55009057 protein_coding
  ENST00000471758 APEX2-002 55000393-55006757 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374987ENST00000471758
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374987 4.800±0.00 4.801±0.00 0.261±0.00 1.271±0.75 3.907±0.00 2.571±0.00 2.521±0.00 4.949±0.00 2.116±1.35 2.117±1.61 1.524±1.22 4.821±3.04 5.654±1.67 2.156±1.11
ENST00000471758 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.405±0.00 2.383±0.00 6.080±0.00 N/A 1.005±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000YC CIL_0000YC_0001 CGP X:55000357-55031064

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0000738 IBA DNA catabolic process, exonucleolytic
GO:0003677 IEA DNA binding
GO:0003906 IBA DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 IEA nuclease activity
GO:0005634 IBA nucleus
GO:0005739 IEA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0006281 IEA DNA repair
GO:0006284 IBA base-excision repair
GO:0006310 IEA DNA recombination
GO:0007049 IEA cell cycle
GO:0008270 IEA zinc ion binding
GO:0008311 IBA double-stranded DNA 3'-5' exodeoxyribonuclease activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008472 apex2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 protein_coding Danio_rerio
ENSDARG00000068961 APEX2 (2 of 2) APEX nuclease (apurinic/apyrimidinic endonuclease) 2 protein_coding Danio_rerio
ENSMUSG00000025269 Apex2 apurinic/apyrimidinic endonuclease 2 protein_coding Mus_musculus

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