C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hypermethylated in cancer 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169635 HIC2 9606 + 22:21417404-21451463 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000407464 HIC2-003 21417404-21451463 protein_coding
  ENST00000407598 HIC2-002 21420636-21449434 protein_coding
  ENST00000443632 HIC2-001 21442460-21451463 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000407464ENST00000407598ENST00000443632
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000407464 1.322±0.00 0.938±0.00 N/A 0.245±0.14 0.419±0.29 0.413±0.34 0.250±0.23 1.217±0.00 0.449±0.00 0.786±0.00 0.147±0.08 2.433±1.76 6.758±2.05 4.671±1.81
ENST00000407598 N/A N/A 0.188±0.00 N/A 0.228±0.00 N/A 0.071±0.00 0.305±0.00 N/A N/A 0.201±0.00 0.573±0.00 N/A 1.309±0.00
ENST00000443632 N/A 0.382±0.00 N/A 0.168±0.07 0.108±0.00 N/A N/A N/A 0.373±0.00 0.319±0.00 N/A 0.364±0.07 N/A 1.122±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PT CIL_0008PT_0001 VISTA 22:21299079-21900013
CIL_0002X8 CIL_0002X8_0001 CGP 22:21383374-21451463

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 NAS DNA binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0008022 IPI protein C-terminus binding
GO:0045892 NAS negative regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045660 hic1l hypermethylated in cancer 1 like protein_coding Danio_rerio
ENSMUSG00000050240 Hic2 hypermethylated in cancer 2 protein_coding Mus_musculus

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