C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: B-cell CLL/lymphoma 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000333681 BCL2-002 ENSG00000171791 9606 - 18:63127035-63319786 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainColonHeartLiverLungMuscleOvaryPlacentaENST00000333681
Transcript ID Bladder Brain Colon Heart Liver Lung Muscle Ovary Placenta
ENST00000333681 2.974±0.00 0.683±0.00 2.113±0.00 0.294±0.00 1.274±0.00 1.276±0.00 1.462±0.32 0.902±0.00 1.114±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00076I CIL_00076I_0001 CGP 18:62715450-63320128
CIL_0000B4 CIL_0000B4_0002 CGP 18:63123346-63367510

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0001836 NAS release of cytochrome c from mitochondria
GO:0002020 IDA protease binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IDA mitochondrial outer membrane
GO:0005783 IDA endoplasmic reticulum
GO:0006915 IDA apoptotic process
GO:0006959 TAS humoral immune response
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0007565 NAS female pregnancy
GO:0008625 IDA extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314 NAS response to radiation
GO:0009636 IDA response to toxic substance
GO:0010039 IDA response to iron ion
GO:0010507 TAS negative regulation of autophagy
GO:0015267 IDA channel activity
GO:0016020 IDA:IEA membrane
GO:0016248 IDA channel inhibitor activity
GO:0022898 IDA regulation of transmembrane transporter activity
GO:0030307 IDA positive regulation of cell growth
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031965 IDA nuclear membrane
GO:0032469 TAS endoplasmic reticulum calcium ion homeostasis
GO:0032848 IDA negative regulation of cellular pH reduction
GO:0034097 IDA response to cytokine
GO:0035094 IDA response to nicotine
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042100 IDA B cell proliferation
GO:0042493 IMP response to drug
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043496 IDA regulation of protein homodimerization activity
GO:0043497 IDA regulation of protein heterodimerization activity
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0045087 TAS innate immune response
GO:0046902 ISS regulation of mitochondrial membrane permeability
GO:0046930 IDA pore complex
GO:0046982 IPI protein heterodimerization activity
GO:0050853 IMP B cell receptor signaling pathway
GO:0051402 TAS neuron apoptotic process
GO:0051434 IPI BH3 domain binding
GO:0051607 IDA defense response to virus
GO:0051881 ISS regulation of mitochondrial membrane potential
GO:0051902 TAS negative regulation of mitochondrial depolarization
GO:0051924 IDA regulation of calcium ion transport
GO:0055085 IDA transmembrane transport
GO:0070059 IDA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000811 IMP negative regulation of anoikis
GO:2001234 IMP negative regulation of apoptotic signaling pathway
GO:2001240 IGI negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IDA negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 TAS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000112751 Bcl2-001 protein_coding Mus_musculus 0 1738
ENSMUST00000189999 Bcl2-002 protein_coding Mus_musculus 0 926

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