C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribonucleotide reductase M2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171848 RRM2 9606 + 2:10122328-10131419 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000304567 RRM2-013 10122730-10131418 protein_coding
  ENST00000360566 RRM2-001 10122328-10131418 protein_coding
  ENST00000459969 RRM2-005 10122712-10124117 retained_intron
  ENST00000461327 RRM2-003 10122739-10123852 retained_intron
  ENST00000462343 RRM2-012 10126791-10127361 retained_intron
  ENST00000474701 RRM2-010 10123171-10129155 protein_coding
  ENST00000485717 RRM2-011 10126830-10129313 retained_intron
  ENST00000487591 RRM2-006 10126512-10127220 retained_intron
  ENST00000491447 RRM2-009 10122752-10124878 retained_intron
  ENST00000498343 RRM2-004 10122739-10123712 retained_intron
  ENST00000615152 RRM2-201 10122568-10131419 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000304567ENST00000360566ENST00000459969ENST00000461327ENST00000474701ENST00000485717ENST00000615152
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000304567 1.027±0.00 0.777±0.00 0.154±0.00 0.123±0.00 0.273±0.00 2.109±1.52 0.450±0.00 0.162±0.00 0.089±0.00 0.410±0.00 0.056±0.03 3.589±2.78 3.724±0.65 2.365±0.77
ENST00000360566 N/A N/A N/A N/A 0.267±0.00 N/A N/A N/A 0.215±0.00 0.247±0.00 N/A N/A N/A N/A
ENST00000459969 N/A N/A N/A N/A N/A N/A N/A 0.185±0.00 N/A N/A N/A N/A N/A N/A
ENST00000461327 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.445±0.00 N/A N/A N/A N/A
ENST00000474701 N/A N/A N/A N/A N/A N/A 0.072±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000485717 N/A N/A 0.485±0.00 0.174±0.00 4.476±0.00 N/A N/A N/A N/A 0.867±0.34 N/A 19.856±7.48 10.095±0.00 3.579±0.00
ENST00000615152 N/A N/A N/A N/A N/A N/A N/A 0.341±0.00 N/A N/A N/A 0.221±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007DI CIL_0007DI_0001 CGP 2:10056780-10131419

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000083 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0004748 ISS ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006260 IEA DNA replication
GO:0009186 IEA deoxyribonucleoside diphosphate metabolic process
GO:0009262 IEA deoxyribonucleotide metabolic process
GO:0009263 ISS deoxyribonucleotide biosynthetic process
GO:0015949 TAS nucleobase-containing small molecule interconversion
GO:0016491 IEA oxidoreductase activity
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0051259 IEA protein oligomerization
GO:0051290 IEA protein heterotetramerization
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020711 rrm2 ribonucleotide reductase M2 polypeptide protein_coding Danio_rerio
ENSDARG00000078069 rrm2 ribonucleotide reductase M2 polypeptide protein_coding Danio_rerio
ENSMUSG00000020649 Rrm2 ribonucleotide reductase M2 protein_coding Mus_musculus

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