C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatase and tensin homolog
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171862 PTEN 9606 + 10:87863113-87971930 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000371953 PTEN-001 87863113-87971930 protein_coding
  ENST00000462694 PTEN-003 87864468-87894326 retained_intron
  ENST00000472832 PTEN-005 87952199-87961309 protein_coding
  ENST00000487939 PTEN-002 87864449-87867049 processed_transcript
  ENST00000498703 PTEN-004 87925523-87933487 retained_intron
  ENST00000610634 PTEN-201 87863438-87942691 protein_coding
  ENST00000618586 PTEN-006 87864501-87866081 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371953ENST00000472832ENST00000498703ENST00000610634
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371953 13.583±0.00 7.574±0.00 3.365±0.00 7.696±1.36 8.890±1.38 9.846±0.65 5.160±0.72 9.964±0.16 7.562±3.61 5.679±0.00 3.176±1.98 7.509±2.57 6.367±0.72 7.455±3.31
ENST00000472832 N/A N/A 9.598±0.00 N/A 13.702±0.00 N/A N/A N/A N/A N/A N/A N/A 16.671±3.62 17.802±0.00
ENST00000498703 N/A N/A 23.361±0.00 47.208±0.00 26.322±0.00 64.688±0.00 N/A 59.635±0.00 45.563±0.00 56.853±0.00 7.115±0.00 69.444±0.00 N/A N/A
ENST00000610634 N/A N/A N/A N/A 9.706±0.00 N/A N/A N/A 17.209±0.00 N/A N/A 12.572±0.00 11.485±3.09 33.266±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001S4 CIL_0001S4_0001 CGP 10:87863113-88584530

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000287 IEA magnesium ion binding
GO:0001525 IEA angiogenesis
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0002902 IEA regulation of B cell apoptotic process
GO:0004438 IDA phosphatidylinositol-3-phosphatase activity
GO:0004721 IDA phosphoprotein phosphatase activity
GO:0004722 IDA protein serine/threonine phosphatase activity
GO:0004725 IDA:IEA protein tyrosine phosphatase activity
GO:0005161 IEA platelet-derived growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006470 IDA:IEA protein dephosphorylation
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0006915 ISS apoptotic process
GO:0007092 IDA activation of mitotic anaphase-promoting complex activity
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007270 ISS neuron-neuron synaptic transmission
GO:0007416 ISS synapse assembly
GO:0007417 ISS central nervous system development
GO:0007507 ISS heart development
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0007611 ISS learning or memory
GO:0007613 IEA memory
GO:0007626 ISS locomotory behavior
GO:0008138 IEA protein tyrosine/serine/threonine phosphatase activity
GO:0008283 TAS cell proliferation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 IMP:IEA negative regulation of cell proliferation
GO:0008289 IEA lipid binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009749 IEA response to glucose
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0010033 IEA response to organic substance
GO:0010035 IEA response to inorganic substance
GO:0010043 IEA response to zinc ion
GO:0010975 ISS regulation of neuron projection development
GO:0010997 IPI anaphase-promoting complex binding
GO:0014067 TAS negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 IEA response to organic cyclic compound
GO:0016311 IEA dephosphorylation
GO:0016314 IDA:IEA phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016477 ISS cell migration
GO:0016791 IEA phosphatase activity
GO:0019899 IPI enzyme binding
GO:0019901 IEA protein kinase binding
GO:0021542 ISS dentate gyrus development
GO:0021955 ISS central nervous system neuron axonogenesis
GO:0030165 IPI:IEA PDZ domain binding
GO:0030336 IMP:IEA negative regulation of cell migration
GO:0031175 IEA neuron projection development
GO:0031642 IEA negative regulation of myelination
GO:0031647 IMP:IEA regulation of protein stability
GO:0031658 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032286 ISS central nervous system myelin maintenance
GO:0032355 IEA response to estradiol
GO:0032535 ISS regulation of cellular component size
GO:0033032 IEA regulation of myeloid cell apoptotic process
GO:0033198 IEA response to ATP
GO:0033555 ISS multicellular organismal response to stress
GO:0035176 ISS social behavior
GO:0035335 IEA peptidyl-tyrosine dephosphorylation
GO:0035749 ISS myelin sheath adaxonal region
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042493 IEA response to drug
GO:0042711 IEA maternal behavior
GO:0042995 IDA cell projection
GO:0043005 ISS neuron projection
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043197 IEA dendritic spine
GO:0043220 ISS Schmidt-Lanterman incisure
GO:0043491 ISS protein kinase B signaling
GO:0043542 IEA endothelial cell migration
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045211 IEA postsynaptic membrane
GO:0045471 IEA response to ethanol
GO:0045475 ISS locomotor rhythm
GO:0045792 ISS negative regulation of cell size
GO:0046621 ISS negative regulation of organ growth
GO:0046685 IEA response to arsenic-containing substance
GO:0046855 IDA:IEA inositol phosphate dephosphorylation
GO:0046856 IMP:IEA phosphatidylinositol dephosphorylation
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048738 IEA cardiac muscle tissue development
GO:0048853 ISS forebrain morphogenesis
GO:0048854 ISS brain morphogenesis
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050765 IEA negative regulation of phagocytosis
GO:0050771 ISS negative regulation of axonogenesis
GO:0050821 IDA protein stabilization
GO:0050852 TAS T cell receptor signaling pathway
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051717 IDA inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051726 IEA regulation of cell cycle
GO:0051800 IDA:IEA phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0051895 IMP:IEA negative regulation of focal adhesion assembly
GO:0051898 IMP:IEA negative regulation of protein kinase B signaling
GO:0060024 ISS rhythmic synaptic transmission
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060074 ISS synapse maturation
GO:0060134 ISS prepulse inhibition
GO:0060179 IEA male mating behavior
GO:0060291 IEA long-term synaptic potentiation
GO:0060292 IEA long term synaptic depression
GO:0060736 IEA prostate gland growth
GO:0060997 ISS dendritic spine morphogenesis
GO:0061002 ISS negative regulation of dendritic spine morphogenesis
GO:0090071 IEA negative regulation of ribosome biogenesis
GO:0090344 IEA negative regulation of cell aging
GO:0090394 ISS negative regulation of excitatory postsynaptic membrane potential
GO:0097105 ISS presynaptic membrane assembly
GO:0097107 ISS postsynaptic density assembly
GO:2000060 IDA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134 IDA negative regulation of G1/S transition of mitotic cell cycle
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000808 ISS negative regulation of synaptic vesicle clustering
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056623 ptenb phosphatase and tensin homolog B protein_coding Danio_rerio
ENSDARG00000071018 ptena phosphatase and tensin homolog A protein_coding Danio_rerio
ENSMUSG00000013663 Pten phosphatase and tensin homolog protein_coding Mus_musculus

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