C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatase and tensin homolog
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000013663 Pten 10090 + 19:32757497-32826160 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000013807 Pten-001 32757497-32826160 protein_coding
  ENSMUST00000140014 Pten-002 32757595-32802843 retained_intron
  ENSMUST00000154806 Pten-003 32811225-32817977 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000013807ENSMUST00000140014
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000013807 14.816±1.96 3.741±0.69 9.081±3.78 10.486±1.29 8.809±1.64 5.313±0.83 5.868±0.35 9.551±0.79 8.835±4.78 13.749±1.09 3.669±0.29 6.394±2.29 5.454±1.95 9.720±2.62
ENSMUST00000140014 N/A 33.476±13.49 N/A N/A 14.737±9.57 18.079±2.29 N/A 3.296±1.50 3.976±0.00 10.701±3.61 N/A 21.199±6.96 N/A 2.084±1.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001S4 CIL_0001S4_0002 CGP 19:32757497-33392295

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001525 IMP angiogenesis
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002902 IMP regulation of B cell apoptotic process
GO:0004438 ISS phosphatidylinositol-3-phosphatase activity
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004722 ISS protein serine/threonine phosphatase activity
GO:0004725 ISS protein tyrosine phosphatase activity
GO:0005161 IEA platelet-derived growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005886 IEA plasma membrane
GO:0006470 ISS protein dephosphorylation
GO:0006915 IEA apoptotic process
GO:0007092 IMP activation of mitotic anaphase-promoting complex activity
GO:0007270 IMP neuron-neuron synaptic transmission
GO:0007416 IMP synapse assembly
GO:0007417 IMP central nervous system development
GO:0007507 IMP heart development
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0007611 IMP learning or memory
GO:0007613 IEA memory
GO:0007626 IMP locomotory behavior
GO:0008138 IEA protein tyrosine/serine/threonine phosphatase activity
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0009749 IEA response to glucose
GO:0009898 IEA cytoplasmic side of plasma membrane
GO:0010033 IEA response to organic substance
GO:0010035 IEA response to inorganic substance
GO:0010043 IEA response to zinc ion
GO:0010975 IMP regulation of neuron projection development
GO:0010997 IEA anaphase-promoting complex binding
GO:0014070 IEA response to organic cyclic compound
GO:0016314 ISS phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016477 IMP cell migration
GO:0019899 IEA enzyme binding
GO:0019901 IPI protein kinase binding
GO:0021542 IMP dentate gyrus development
GO:0021955 IMP central nervous system neuron axonogenesis
GO:0030165 ISS PDZ domain binding
GO:0030336 ISS negative regulation of cell migration
GO:0031175 IEA neuron projection development
GO:0031642 IMP negative regulation of myelination
GO:0031647 ISS regulation of protein stability
GO:0031658 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032286 IMP central nervous system myelin maintenance
GO:0032355 IEA response to estradiol
GO:0032535 IMP regulation of cellular component size
GO:0033032 IMP regulation of myeloid cell apoptotic process
GO:0033198 IEA response to ATP
GO:0033555 IMP multicellular organismal response to stress
GO:0035176 IMP social behavior
GO:0035335 IEA peptidyl-tyrosine dephosphorylation
GO:0035749 IDA myelin sheath adaxonal region
GO:0042493 IEA response to drug
GO:0042711 IMP maternal behavior
GO:0042995 IEA cell projection
GO:0043005 IDA neuron projection
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043197 IEA dendritic spine
GO:0043220 IDA Schmidt-Lanterman incisure
GO:0043491 IMP protein kinase B signaling
GO:0043542 IMP endothelial cell migration
GO:0045211 IEA postsynaptic membrane
GO:0045471 IEA response to ethanol
GO:0045475 IMP locomotor rhythm
GO:0045792 IMP negative regulation of cell size
GO:0046621 IMP negative regulation of organ growth
GO:0046685 IEA response to arsenic-containing substance
GO:0046855 ISS inositol phosphate dephosphorylation
GO:0046856 ISS phosphatidylinositol dephosphorylation
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048738 IMP cardiac muscle tissue development
GO:0048853 IMP forebrain morphogenesis
GO:0048854 IMP brain morphogenesis
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050765 IEA negative regulation of phagocytosis
GO:0050771 IMP negative regulation of axonogenesis
GO:0050821 IEA protein stabilization
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051717 ISS inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051726 IGI regulation of cell cycle
GO:0051800 ISS phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0051895 ISS negative regulation of focal adhesion assembly
GO:0051898 IMP negative regulation of protein kinase B signaling
GO:0060024 IMP rhythmic synaptic transmission
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060074 IMP synapse maturation
GO:0060134 IMP prepulse inhibition
GO:0060179 IMP male mating behavior
GO:0060291 IMP long-term synaptic potentiation
GO:0060292 IEA long term synaptic depression
GO:0060736 IMP prostate gland growth
GO:0060997 IMP dendritic spine morphogenesis
GO:0061002 IMP negative regulation of dendritic spine morphogenesis
GO:0090071 IMP negative regulation of ribosome biogenesis
GO:0090344 IMP negative regulation of cell aging
GO:0090394 IMP negative regulation of excitatory postsynaptic membrane potential
GO:0097105 IMP presynaptic membrane assembly
GO:0097107 IMP postsynaptic density assembly
GO:2000060 IEA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134 IEA negative regulation of G1/S transition of mitotic cell cycle
GO:2000463 IMP positive regulation of excitatory postsynaptic membrane potential
GO:2000808 IMP negative regulation of synaptic vesicle clustering
GO:2001235 IMP positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056623 ptenb phosphatase and tensin homolog B protein_coding Danio_rerio
ENSDARG00000071018 ptena phosphatase and tensin homolog A protein_coding Danio_rerio
ENSG00000171862 PTEN phosphatase and tensin homolog protein_coding Homo_sapiens

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