C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase 1, catalytic subunit, alpha isozyme
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000172531 PPP1CA 9606 - 11:67398183-67421183 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000312989 PPP1CA-002 67398183-67401793 protein_coding
  ENST00000358239 PPP1CA-006 67398431-67401871 protein_coding
  ENST00000376745 PPP1CA-001 67398201-67401931 protein_coding
  ENST00000526510 PPP1CA-003 67398201-67401604 retained_intron
  ENST00000527663 PPP1CA-007 67398740-67401788 protein_coding
  ENST00000529724 PPP1CA-005 67400716-67401815 processed_transcript
  ENST00000532279 PPP1CA-008 67398582-67399606 processed_transcript
  ENST00000532446 PPP1CA-004 67398201-67401577 processed_transcript
  ENST00000537694 PPP1CA-009 67398936-67407264 processed_transcript
  ENST00000542876 PPP1CA-010 67400859-67421183 protein_coding
  ENST00000546202 PPP1CA-011 67400855-67421181 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000312989ENST00000358239ENST00000376745ENST00000527663ENST00000532446
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000312989 16.021±0.00 48.484±0.00 N/A N/A 21.462±0.00 18.817±0.00 N/A 51.925±0.00 14.675±0.00 32.726±0.00 16.481±0.00 22.133±3.63 27.043±1.15 20.679±0.00
ENST00000358239 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 29.809±0.00 N/A
ENST00000376745 35.514±0.00 102.921±0.00 11.630±0.00 8.098±0.00 33.349±10.76 28.768±8.31 21.654±16.13 27.647±21.56 23.252±13.44 27.005±12.98 37.743±20.64 43.262±24.17 93.694±29.26 27.087±15.80
ENST00000527663 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 100.709±0.00 88.373±0.00 27.836±0.00
ENST00000532446 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.453±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000164 IEA protein phosphatase type 1 complex
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004722 IEA protein serine/threonine phosphatase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005977 IEA glycogen metabolic process
GO:0005979 IEA regulation of glycogen biosynthetic process
GO:0005981 IEA regulation of glycogen catabolic process
GO:0006470 ISS protein dephosphorylation
GO:0007049 IEA cell cycle
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0016311 IEA dephosphorylation
GO:0016787 IEA hydrolase activity
GO:0016791 ISS phosphatase activity
GO:0019433 TAS triglyceride catabolic process
GO:0030324 IEA lung development
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032922 ISS circadian regulation of gene expression
GO:0042587 IEA glycogen granule
GO:0042752 IMP regulation of circadian rhythm
GO:0043005 IEA neuron projection
GO:0043021 IEA ribonucleoprotein complex binding
GO:0043025 IEA neuronal cell body
GO:0043153 ISS entrainment of circadian clock by photoperiod
GO:0043197 IEA dendritic spine
GO:0043204 IEA perikaryon
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0051301 IEA cell division
GO:0070062 IDA extracellular vesicular exosome
GO:0070688 IDA MLL5-L complex
GO:0072357 IDA PTW/PP1 phosphatase complex
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003486 ppp1caa protein phosphatase 1, catalytic subunit, alpha isoform a protein_coding Danio_rerio
ENSDARG00000071566 ppp1cab protein phosphatase 1, catalytic subunit, alpha isoform b protein_coding Danio_rerio
ENSMUSG00000040385 Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform protein_coding Mus_musculus

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