C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cofilin 1 (non-muscle)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000172757 CFL1 9606 - 11:65823022-65862026 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308162 CFL1-201 65854837-65858333 protein_coding
  ENST00000524553 CFL1-014 65855054-65856964 protein_coding
  ENST00000525451 CFL1-001 65854675-65859415 protein_coding
  ENST00000525710 CFL1-010 65826322-65831770 processed_transcript
  ENST00000526975 CFL1-008 65855974-65859282 protein_coding
  ENST00000527344 CFL1-013 65854975-65857033 protein_coding
  ENST00000527752 CFL1-009 65823022-65858157 processed_transcript
  ENST00000530157 CFL1-011 65823022-65824103 processed_transcript
  ENST00000530413 CFL1-015 65855418-65856473 protein_coding
  ENST00000530945 CFL1-003 65854832-65858194 retained_intron
  ENST00000531407 CFL1-002 65855009-65857868 protein_coding
  ENST00000531413 CFL1-007 65855257-65859289 protein_coding
  ENST00000532134 CFL1-005 65855358-65862026 protein_coding
  ENST00000534769 CFL1-006 65855241-65861421 protein_coding
  ENST00000534784 CFL1-012 65855957-65857543 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308162ENST00000525451ENST00000526975ENST00000527344ENST00000530413ENST00000531407ENST00000531413
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308162 362.303±0.00 459.879±0.00 N/A 175.828±132.72 132.631±114.99 150.696±110.83 111.402±104.80 160.311±137.23 133.635±107.61 385.056±374.57 53.356±44.76 413.365±40.44 698.763±198.38 185.939±45.65
ENST00000525451 N/A N/A N/A N/A N/A 10.356±0.00 3.078±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000526975 N/A N/A 13.258±0.00 62.834±0.00 54.146±0.00 50.040±0.00 N/A N/A N/A 23.264±0.00 N/A 239.886±155.42 329.619±0.00 123.103±0.00
ENST00000527344 N/A N/A 12.981±0.00 N/A 13.975±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000530413 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.219±0.00 N/A N/A N/A
ENST00000531407 145.728±0.00 215.640±0.00 N/A 143.381±0.00 85.115±0.00 159.003±0.00 N/A 176.225±0.00 N/A N/A N/A N/A N/A 88.358±0.00
ENST00000531413 N/A N/A N/A N/A N/A 21.680±0.00 N/A 11.755±0.00 N/A 13.913±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002MN CIL_0002MN_0001 CGP 11:65823022-65862026

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000281 IEA mitotic cytokinesis
GO:0001755 IEA neural crest cell migration
GO:0001842 IEA neural fold formation
GO:0002576 TAS platelet degranulation
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005622 IEA intracellular
GO:0005634 TAS nucleus
GO:0005737 TAS cytoplasm
GO:0005886 IEA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0006606 IEA protein import into nucleus
GO:0006928 IEA cellular component movement
GO:0007010 IMP cytoskeleton organization
GO:0007015 IEA actin filament organization
GO:0007266 TAS Rho protein signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0009615 IEP response to virus
GO:0015629 IEA actin cytoskeleton
GO:0016020 IDA membrane
GO:0022604 IMP regulation of cell morphogenesis
GO:0030010 IEA establishment of cell polarity
GO:0030027 IEA lamellipodium
GO:0030030 IEA cell projection organization
GO:0030036 TAS actin cytoskeleton organization
GO:0030042 IEA actin filament depolymerization
GO:0030168 TAS platelet activation
GO:0030836 IEA positive regulation of actin filament depolymerization
GO:0030864 IEA cortical actin cytoskeleton
GO:0031252 IEA cell leading edge
GO:0031982 IDA vesicle
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043066 TAS negative regulation of apoptotic process
GO:0043200 IEA response to amino acid
GO:0045087 TAS innate immune response
GO:0045792 IEA negative regulation of cell size
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021124 cfl1 cofilin 1 protein_coding Danio_rerio
ENSMUSG00000056201 Cfl1 cofilin 1, non-muscle protein_coding Mus_musculus

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