C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-rel avian reticuloendotheliosis viral oncogene homolog A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173039 RELA 9606 - 11:65653596-65663094 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308639 RELA-002 65653602-65663090 protein_coding
  ENST00000406246 RELA-001 65653596-65663094 protein_coding
  ENST00000525301 RELA-012 65660156-65662918 retained_intron
  ENST00000525658 RELA-017 65658287-65662915 nonsense_mediated_decay
  ENST00000525693 RELA-006 65653601-65662895 protein_coding
  ENST00000525858 RELA-010 65661408-65662972 retained_intron
  ENST00000526257 RELA-007 65655707-65659743 protein_coding
  ENST00000526283 RELA-008 65653602-65662895 nonsense_mediated_decay
  ENST00000526738 RELA-019 65658602-65660792 retained_intron
  ENST00000527074 RELA-026 65660052-65662918 retained_intron
  ENST00000527749 RELA-014 65658732-65662792 protein_coding
  ENST00000527874 RELA-016 65660189-65662428 protein_coding
  ENST00000527909 RELA-023 65658718-65662908 nonsense_mediated_decay
  ENST00000529330 RELA-020 65658769-65660162 retained_intron
  ENST00000529389 RELA-025 65655857-65662960 nonsense_mediated_decay
  ENST00000531238 RELA-021 65659744-65662908 nonsense_mediated_decay
  ENST00000531484 RELA-005 65653967-65662915 retained_intron
  ENST00000532776 RELA-011 65661633-65662944 retained_intron
  ENST00000532879 RELA-027 65659682-65662915 protein_coding
  ENST00000532999 RELA-004 65654812-65662918 protein_coding
  ENST00000533187 RELA-013 65660172-65662793 protein_coding
  ENST00000533546 RELA-024 65658430-65662908 nonsense_mediated_decay
  ENST00000534283 RELA-015 65661943-65662780 protein_coding
  ENST00000534305 RELA-018 65661511-65662897 retained_intron
  ENST00000534558 RELA-022 65658730-65662899 protein_coding
  ENST00000612991 RELA-201 65653599-65662972 protein_coding
  ENST00000615805 RELA-202 65653597-65662972 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308639ENST00000406246ENST00000525693ENST00000526283ENST00000529389ENST00000531238ENST00000532999ENST00000533187ENST00000612991
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308639 9.453±0.00 N/A N/A 3.443±2.92 N/A 4.574±3.59 N/A 5.847±0.00 1.326±0.00 N/A N/A N/A N/A 8.004±0.00
ENST00000406246 24.201±0.00 21.238±0.00 N/A 2.839±1.94 16.063±0.00 N/A 15.190±0.00 5.905±0.00 10.899±0.00 45.646±0.00 27.363±0.00 32.672±19.67 17.263±0.43 12.987±1.81
ENST00000525693 N/A N/A N/A 0.320±0.00 1.337±0.00 4.481±0.00 N/A N/A N/A 17.385±0.00 N/A N/A N/A N/A
ENST00000526283 N/A N/A N/A N/A N/A 1.224±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000529389 N/A N/A N/A N/A N/A 2.725±0.00 N/A N/A 2.931±0.00 2.610±0.00 2.723±0.00 27.115±25.41 25.205±0.00 25.850±0.00
ENST00000531238 N/A N/A N/A N/A N/A N/A 2.063±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000532999 N/A N/A 2.285±0.00 N/A N/A N/A N/A N/A 2.237±0.00 1.509±0.00 N/A 21.884±0.00 N/A N/A
ENST00000533187 N/A N/A N/A 1.963±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000612991 19.593±0.00 27.399±0.00 N/A 7.142±0.00 9.717±0.00 12.411±0.00 N/A 10.185±0.00 7.106±0.00 N/A 2.159±0.00 6.614±5.80 5.085±0.51 12.411±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008W1 CIL_0008W1_0001 VISTA 11:65187233-65790923

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001205 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001889 IEA liver development
GO:0001942 IEA hair follicle development
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006117 IEA acetaldehyde metabolic process
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006952 IEA defense response
GO:0006954 IDA inflammatory response
GO:0006968 NAS cellular defense response
GO:0007568 IEA aging
GO:0008134 IPI transcription factor binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0009612 IEA response to mechanical stimulus
GO:0009617 IEA response to bacterium
GO:0009887 IEA organ morphogenesis
GO:0010033 IDA response to organic substance
GO:0010035 IEA response to inorganic substance
GO:0010224 IDA response to UV-B
GO:0014040 IEA positive regulation of Schwann cell differentiation
GO:0014070 IEA response to organic cyclic compound
GO:0016032 IEA viral process
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019899 IEA enzyme binding
GO:0019901 IPI protein kinase binding
GO:0031293 TAS membrane protein intracellular domain proteolysis
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032332 IEA positive regulation of chondrocyte differentiation
GO:0032403 IEA protein complex binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0032495 IEA response to muramyl dipeptide
GO:0032496 IEA response to lipopolysaccharide
GO:0032570 IEA response to progesterone
GO:0032868 IEA response to insulin
GO:0033590 IEA response to cobalamin
GO:0033613 IPI activating transcription factor binding
GO:0034097 IEA response to cytokine
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042301 IDA phosphate ion binding
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042802 IPI identical protein binding
GO:0043066 IDA negative regulation of apoptotic process
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 IEA response to amino acid
GO:0043234 IEA protein complex
GO:0043278 IEA response to morphine
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045084 IEA positive regulation of interleukin-12 biosynthetic process
GO:0045087 TAS innate immune response
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046627 IEA negative regulation of insulin receptor signaling pathway
GO:0047485 IPI protein N-terminus binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050727 ISS regulation of inflammatory response
GO:0050852 TAS T cell receptor signaling pathway
GO:0051059 IPI NF-kappaB binding
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051591 IEA response to cAMP
GO:0051607 NAS defense response to virus
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0070431 IDA nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070491 IPI repressing transcription factor binding
GO:0070555 IGI response to interleukin-1
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071316 IMP cellular response to nicotine
GO:0071347 IDA cellular response to interleukin-1
GO:0071354 IMP cellular response to interleukin-6
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071375 IMP cellular response to peptide hormone stimulus
GO:0071532 IEA ankyrin repeat binding
GO:2000630 IMP positive regulation of miRNA metabolic process
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021907 rela v-rel reticuloendotheliosis viral oncogene homolog A protein_coding Danio_rerio
ENSMUSG00000024927 Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) protein_coding Mus_musculus

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