C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leptin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000174697 LEP 9606 + 7:128241284-128257628 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308868 LEP-001 128241284-128257628 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308868
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308868 18.693±0.00 0.257±0.00 0.045±0.00 180.637±172.66 0.389±0.07 0.676±0.10 0.091±0.00 0.974±0.96 0.180±0.11 0.036±0.00 0.105±0.10 5.835±3.35 0.276±0.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Y6 CIL_0004Y6_0002 CGP 7:128027071-128257628
CIL_0006HQ CIL_0006HQ_0002 CGP 7:128241284-128343908

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001542 IEA ovulation from ovarian follicle
GO:0001666 IEA response to hypoxia
GO:0001819 IEA positive regulation of cytokine production
GO:0001890 IDA placenta development
GO:0001932 IEA regulation of protein phosphorylation
GO:0002021 IEA response to dietary excess
GO:0005179 IEA hormone activity
GO:0005515 IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 ISS extracellular space
GO:0005737 IEA cytoplasm
GO:0006006 IEA glucose metabolic process
GO:0006111 IEA regulation of gluconeogenesis
GO:0006112 IEA energy reserve metabolic process
GO:0006114 IEA glycerol biosynthetic process
GO:0006629 IEA lipid metabolic process
GO:0006635 IEA fatty acid beta-oxidation
GO:0007165 IEA signal transduction
GO:0007260 IEA tyrosine phosphorylation of STAT protein
GO:0007565 IEA female pregnancy
GO:0007584 IEA response to nutrient
GO:0007623 IEA circadian rhythm
GO:0008083 IEA growth factor activity
GO:0008203 IEA cholesterol metabolic process
GO:0008206 IEA bile acid metabolic process
GO:0008217 IEA regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0008343 ISS adult feeding behavior
GO:0009062 IEA fatty acid catabolic process
GO:0009892 IEA negative regulation of metabolic process
GO:0019222 IEA regulation of metabolic process
GO:0021954 IEA central nervous system neuron development
GO:0030073 IEA insulin secretion
GO:0030300 IEA regulation of intestinal cholesterol absorption
GO:0032099 ISS negative regulation of appetite
GO:0032868 IEA response to insulin
GO:0033197 IEA response to vitamin E
GO:0033210 IEA leptin-mediated signaling pathway
GO:0033686 IEA positive regulation of luteinizing hormone secretion
GO:0035630 IEA bone mineralization involved in bone maturation
GO:0042307 IEA positive regulation of protein import into nucleus
GO:0042445 IEA hormone metabolic process
GO:0042517 IEA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593 IEA glucose homeostasis
GO:0042755 IEA eating behavior
GO:0043066 IEA negative regulation of apoptotic process
GO:0043270 IEA positive regulation of ion transport
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045598 IEA regulation of fat cell differentiation
GO:0045639 IEA positive regulation of myeloid cell differentiation
GO:0045906 IEA negative regulation of vasoconstriction
GO:0046427 IEA positive regulation of JAK-STAT cascade
GO:0046628 IEA positive regulation of insulin receptor signaling pathway
GO:0046881 IEA positive regulation of follicle-stimulating hormone secretion
GO:0048639 IDA positive regulation of developmental growth
GO:0050796 IEA regulation of insulin secretion
GO:0050810 IEA regulation of steroid biosynthetic process
GO:0050901 IEA leukocyte tethering or rolling
GO:0051428 IEA peptide hormone receptor binding
GO:0060587 IEA regulation of lipoprotein lipid oxidation
GO:0060612 IEA adipose tissue development
GO:0061037 IEA negative regulation of cartilage development
GO:0070093 IEA negative regulation of glucagon secretion
GO:0071298 IEA cellular response to L-ascorbic acid
GO:0071300 IEA cellular response to retinoic acid
GO:1900180 IEA regulation of protein localization to nucleus
GO:2000366 IEA positive regulation of STAT protein import into nucleus
GO:2000486 IEA negative regulation of glutamine transport
GO:2000491 IEA positive regulation of hepatic stellate cell activation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091085 lepa leptin a protein_coding Danio_rerio
ENSMUSG00000059201 Lep leptin protein_coding Mus_musculus

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