C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leptin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000059201 Lep 10090 + 6:29060220-29073877 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000069789 Lep-001 29060220-29073877 protein_coding
  ENSMUST00000169505 Lep-002 29065462-29070972 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000069789ENSMUST00000169505
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000069789 372.090±312.67 9.265±2.65 1.451±0.87 0.008±0.01 69.016±4.53 1.021±0.17 0.814±0.21 1.322±0.57 0.013±0.00 1.749±0.62 0.576±0.54 7.751±1.22 0.455±0.45 0.536±0.13
ENSMUST00000169505 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.034±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Y6 CIL_0004Y6_0003 CGP 6:28661831-29073877
CIL_0006HQ CIL_0006HQ_0003 CGP 6:29060220-29165006

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001542 IEA ovulation from ovarian follicle
GO:0001666 IEA response to hypoxia
GO:0001819 IEA positive regulation of cytokine production
GO:0001890 IEA placenta development
GO:0001932 IDA regulation of protein phosphorylation
GO:0002021 IGI response to dietary excess
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0006006 IMP glucose metabolic process
GO:0006111 IMP regulation of gluconeogenesis
GO:0006112 IEA energy reserve metabolic process
GO:0006114 IEA glycerol biosynthetic process
GO:0006629 IMP lipid metabolic process
GO:0006635 IGI fatty acid beta-oxidation
GO:0007260 IDA tyrosine phosphorylation of STAT protein
GO:0007565 IEA female pregnancy
GO:0007584 IEA response to nutrient
GO:0007623 IEA circadian rhythm
GO:0008083 IDA growth factor activity
GO:0008203 IGI cholesterol metabolic process
GO:0008206 IDA bile acid metabolic process
GO:0008217 IEA regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0008343 IDA adult feeding behavior
GO:0009062 IEA fatty acid catabolic process
GO:0009892 IEA negative regulation of metabolic process
GO:0019222 IMP regulation of metabolic process
GO:0021954 IMP central nervous system neuron development
GO:0030073 IGI insulin secretion
GO:0030300 IDA regulation of intestinal cholesterol absorption
GO:0032099 IDA negative regulation of appetite
GO:0032868 IMP response to insulin
GO:0033197 IEA response to vitamin E
GO:0033210 IEA leptin-mediated signaling pathway
GO:0033686 IEA positive regulation of luteinizing hormone secretion
GO:0035630 IEA bone mineralization involved in bone maturation
GO:0042307 IDA positive regulation of protein import into nucleus
GO:0042445 IMP hormone metabolic process
GO:0042517 IEA positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593 IGI glucose homeostasis
GO:0042755 IGI eating behavior
GO:0043066 IEA negative regulation of apoptotic process
GO:0043270 IEA positive regulation of ion transport
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045598 IGI regulation of fat cell differentiation
GO:0045639 IDA positive regulation of myeloid cell differentiation
GO:0045906 IEA negative regulation of vasoconstriction
GO:0046427 IDA positive regulation of JAK-STAT cascade
GO:0046628 IEA positive regulation of insulin receptor signaling pathway
GO:0046881 IEA positive regulation of follicle-stimulating hormone secretion
GO:0048639 IEA positive regulation of developmental growth
GO:0050796 IMP regulation of insulin secretion
GO:0050810 IMP regulation of steroid biosynthetic process
GO:0050901 IEA leukocyte tethering or rolling
GO:0051428 IEA peptide hormone receptor binding
GO:0060587 IEA regulation of lipoprotein lipid oxidation
GO:0060612 IGI adipose tissue development
GO:0061037 IEA negative regulation of cartilage development
GO:0070093 IDA negative regulation of glucagon secretion
GO:0071298 IEA cellular response to L-ascorbic acid
GO:0071300 IEA cellular response to retinoic acid
GO:1900180 IMP regulation of protein localization to nucleus
GO:2000366 IDA positive regulation of STAT protein import into nucleus
GO:2000486 IEA negative regulation of glutamine transport
GO:2000491 IEA positive regulation of hepatic stellate cell activation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091085 lepa leptin a protein_coding Danio_rerio
ENSG00000174697 LEP leptin protein_coding Homo_sapiens

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