C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Harvey rat sarcoma viral oncogene homolog
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000174775 HRAS 9606 - 11:532242-537287 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311189 HRAS-002 532376-535534 protein_coding
  ENST00000397594 HRAS-004 532242-534375 protein_coding
  ENST00000397596 HRAS-009 532242-535339 protein_coding
  ENST00000417302 HRAS-201 532243-535550 protein_coding
  ENST00000451590 HRAS-202 532243-535550 protein_coding
  ENST00000462734 HRAS-005 532246-533595 processed_transcript
  ENST00000468682 HRAS-003 533795-537287 processed_transcript
  ENST00000478324 HRAS-007 532242-533612 processed_transcript
  ENST00000479482 HRAS-008 532642-533976 processed_transcript
  ENST00000482021 HRAS-010 534279-534587 processed_transcript
  ENST00000493230 HRAS-001 532242-535538 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000311189ENST00000397594ENST00000397596ENST00000417302ENST00000451590ENST00000462734ENST00000468682ENST00000478324ENST00000479482ENST00000493230
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000311189 7.209±0.00 6.080±0.00 N/A 8.117±4.45 16.743±0.00 5.269±4.25 8.565±0.00 8.459±6.81 1.746±0.85 15.313±0.00 7.649±6.80 1.969±1.89 18.016±11.59 6.612±0.66
ENST00000397594 2.533±0.00 N/A N/A N/A N/A N/A 0.267±0.00 N/A N/A 3.734±0.00 N/A 3.672±3.13 N/A 5.544±3.15
ENST00000397596 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.742±0.00 7.583±0.00 N/A
ENST00000417302 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.344±0.00 N/A N/A N/A N/A
ENST00000451590 N/A N/A N/A 2.514±0.00 0.146±0.00 6.590±0.00 2.771±0.00 N/A 1.028±0.00 2.931±0.00 N/A N/A 4.124±0.00 N/A
ENST00000462734 13.204±0.00 15.934±0.00 0.819±0.00 28.070±0.00 23.092±0.00 9.581±9.36 2.582±2.40 17.134±0.00 1.881±1.42 9.991±0.00 9.549±0.00 7.073±0.00 11.852±3.57 7.094±3.76
ENST00000468682 N/A N/A 0.380±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000478324 N/A N/A 0.358±0.00 N/A N/A N/A N/A N/A N/A N/A 0.617±0.00 6.136±0.00 N/A N/A
ENST00000479482 6.058±0.00 N/A N/A 15.057±0.00 10.550±9.19 12.653±0.00 N/A N/A N/A N/A 4.833±1.83 36.478±0.00 26.359±0.00 9.640±0.15
ENST00000493230 N/A N/A N/A N/A N/A 4.311±0.00 N/A N/A N/A N/A N/A 8.111±4.33 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003OR CIL_0003OR_0001 CGP 11:494512-537287
CIL_00040A CIL_00040A_0002 CGP 11:532242-554916

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0003924 IEA GTPase activity
GO:0005515 IPI protein binding
GO:0005525 IDA:IEA GTP binding
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005737 TAS cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006184 IEA GTP catabolic process
GO:0006897 IEA endocytosis
GO:0006915 IEA apoptotic process
GO:0006935 TAS chemotaxis
GO:0007050 IDA cell cycle arrest
GO:0007093 IDA mitotic cell cycle checkpoint
GO:0007165 NAS:IEA signal transduction
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS:IEA small GTPase mediated signal transduction
GO:0007265 IDA Ras protein signal transduction
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0007569 IEA cell aging
GO:0007596 TAS blood coagulation
GO:0008022 IPI protein C-terminus binding
GO:0008283 IEA cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008542 IEA visual learning
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009887 TAS organ morphogenesis
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0015031 IEA protein transport
GO:0015093 IEA ferrous iron transmembrane transporter activity
GO:0015684 IEA ferrous iron transport
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030036 IEA actin cytoskeleton organization
GO:0030335 IDA positive regulation of cell migration
GO:0032228 IEA regulation of synaptic transmission, GABAergic
GO:0032855 IDA positive regulation of Rac GTPase activity
GO:0034259 IDA negative regulation of Rho GTPase activity
GO:0035022 IEA positive regulation of Rac protein signal transduction
GO:0035176 IEA social behavior
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045087 TAS innate immune response
GO:0045596 IEA negative regulation of cell differentiation
GO:0045740 IDA positive regulation of DNA replication
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0046579 IEA positive regulation of Ras protein signal transduction
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050900 TAS leukocyte migration
GO:0051146 IEA striated muscle cell differentiation
GO:0051291 IEA protein heterooligomerization
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0090303 IDA positive regulation of wound healing
GO:0090398 IDA cellular senescence
GO:0097193 IEA intrinsic apoptotic signaling pathway
GO:1900029 IDA positive regulation of ruffle assembly
GO:2000251 IDA positive regulation of actin cytoskeleton reorganization
GO:2000630 IDA positive regulation of miRNA metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005651 hrasb -Ha-ras Harvey rat sarcoma viral oncogene homolog b protein_coding Danio_rerio
ENSDARG00000070524 hrasa v-Ha-ras Harvey rat sarcoma viral oncogene homolog a protein_coding Danio_rerio
ENSMUSG00000025499 Hras Harvey rat sarcoma virus oncogene protein_coding Mus_musculus

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