C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ubiquitin-conjugating enzyme E2N
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177889 UBE2N 9606 - 12:93405673-93442262 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000318066 UBE2N-001 93405690-93442262 protein_coding
  ENST00000548946 UBE2N-006 93405673-93407323 processed_transcript
  ENST00000549490 UBE2N-005 93409763-93441898 nonsense_mediated_decay
  ENST00000549833 UBE2N-002 93409742-93441256 protein_coding
  ENST00000550657 UBE2N-004 93408371-93441943 protein_coding
  ENST00000552442 UBE2N-003 93409801-93441935 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungOvaryPlacentaTestisENST00000318066ENST00000549490ENST00000549833ENST00000550657
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Ovary Placenta Testis
ENST00000318066 N/A 9.197±0.00 8.424±0.17 N/A 3.781±0.00 10.782±0.00 N/A 3.228±0.48 5.630±0.00 N/A 8.135±0.00
ENST00000549490 N/A N/A N/A N/A N/A N/A 16.080±0.00 N/A N/A N/A 80.247±13.06
ENST00000549833 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 61.841±0.00
ENST00000550657 8.149±0.00 N/A N/A 8.627±0.00 8.598±0.00 N/A 3.094±0.00 N/A 11.773±0.57 12.632±2.92 17.727±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000XV CIL_0000XV_0002 CGP 12:93377883-93442262
CIL_0005X9 CIL_0005X9_0002 CGP 12:93405673-93516213

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000724 IMP double-strand break repair via homologous recombination
GO:0000729 IMP DNA double-strand break processing
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006282 TAS regulation of DNA repair
GO:0006301 IMP postreplication repair
GO:0006464 TAS cellular protein modification process
GO:0006508 TAS proteolysis
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0008152 IEA metabolic process
GO:0016567 TAS protein ubiquitination
GO:0016574 IMP histone ubiquitination
GO:0016881 IEA acid-amino acid ligase activity
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0031058 IMP positive regulation of histone modification
GO:0031372 IDA UBC13-MMS2 complex
GO:0033182 IMP regulation of histone ubiquitination
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035370 IDA UBC13-UEV1A complex
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 IDA ubiquitin binding
GO:0043234 IDA protein complex
GO:0044822 IDA poly(A) RNA binding
GO:0045087 TAS innate immune response
GO:0045739 IMP positive regulation of DNA repair
GO:0050852 IMP T cell receptor signaling pathway
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051443 IMP positive regulation of ubiquitin-protein transferase activity
GO:0070062 IDA extracellular vesicular exosome
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 IDA protein K63-linked ubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008748 ube2na ubiquitin-conjugating enzyme E2Na protein_coding Danio_rerio
ENSDARG00000045877 ube2nb ubiquitin-conjugating enzyme E2Nb protein_coding Danio_rerio
ENSMUSG00000074781 Ube2n ubiquitin-conjugating enzyme E2N protein_coding Mus_musculus

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