C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD28 molecule
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000178562 CD28 9606 + 2:203706475-203738912 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000324106 CD28-001 203706548-203738912 protein_coding
  ENST00000374481 CD28-201 203706475-203738910 protein_coding
  ENST00000458610 CD28-002 203706524-203734912 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000324106ENST00000374481ENST00000458610
Transcript ID Adipose Adrenal Brain Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000324106 0.266±0.00 1.732±0.00 0.043±0.00 N/A 0.010±0.00 N/A 1.405±0.00 N/A 0.210±0.10 2.452±0.47 N/A
ENST00000374481 N/A N/A N/A 0.094±0.00 N/A 0.176±0.00 0.389±0.00 0.024±0.00 0.280±0.00 0.703±0.00 0.247±0.13
ENST00000458610 N/A N/A N/A N/A N/A 0.683±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001QX CIL_0001QX_0001 CGP 2:203394345-203738912
CIL_000398 CIL_000398_0001 CGP 2:203706475-203873960

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IEA immunological synapse
GO:0002020 IPI protease binding
GO:0002863 IEA positive regulation of inflammatory response to antigenic stimulus
GO:0005070 IDA SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006959 TAS humoral immune response
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009897 IDA external side of plasma membrane
GO:0009967 IDA positive regulation of signal transduction
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015026 TAS coreceptor activity
GO:0016032 TAS viral process
GO:0031295 TAS T cell costimulation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042089 TAS cytokine biosynthetic process
GO:0042102 ISS positive regulation of T cell proliferation
GO:0042802 NAS identical protein binding
GO:0045060 IEA negative thymic T cell selection
GO:0045066 IDA regulatory T cell differentiation
GO:0045070 NAS positive regulation of viral genome replication
GO:0045086 ISS positive regulation of interleukin-2 biosynthetic process
GO:0045087 TAS innate immune response
GO:0045727 NAS positive regulation of translation
GO:0045840 ISS positive regulation of mitosis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046641 IEA positive regulation of alpha-beta T cell proliferation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048304 IEA positive regulation of isotype switching to IgG isotypes
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050852 IEA T cell receptor signaling pathway
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0097190 IEA apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000026012 Cd28 CD28 antigen protein_coding Mus_musculus

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