C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000178568 ERBB4 9606 - 2:211375717-212538841 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260943 ERBB4-004 211619253-212538529 protein_coding
  ENST00000342788 ERBB4-001 211375717-212538841 protein_coding
  ENST00000402597 ERBB4-201 211375717-212124915 protein_coding
  ENST00000435846 ERBB4-005 211750699-212429247 protein_coding
  ENST00000436443 ERBB4-002 211375721-212538841 protein_coding
  ENST00000459774 ERBB4-007 212124584-212125181 retained_intron
  ENST00000463121 ERBB4-008 211657597-211665354 processed_transcript
  ENST00000484474 ERBB4-006 211725152-211960762 processed_transcript
  ENST00000484594 ERBB4-003 211561762-212538582 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260943ENST00000342788ENST00000402597ENST00000436443ENST00000459774ENST00000484594
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260943 N/A N/A N/A 0.378±0.00 N/A N/A N/A N/A N/A 1.395±0.00 N/A 0.029±0.02 N/A
ENST00000342788 N/A 1.749±0.00 0.796±0.00 N/A N/A N/A N/A N/A N/A 0.220±0.00 0.089±0.00 N/A 0.677±0.29
ENST00000402597 0.062±0.00 N/A 1.396±0.00 0.331±0.07 0.052±0.03 N/A 0.352±0.34 0.002±0.00 0.205±0.00 0.314±0.00 0.084±0.00 0.014±0.01 0.256±0.08
ENST00000436443 N/A N/A 1.945±0.00 N/A N/A 0.180±0.00 2.074±0.00 0.001±0.00 N/A 0.522±0.00 0.429±0.00 N/A 0.529±0.35
ENST00000459774 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.099±0.00 N/A
ENST00000484594 N/A 2.668±0.00 N/A 0.516±0.00 0.121±0.00 N/A N/A 0.554±0.00 N/A N/A 0.203±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000164 CIL_000164_0001 CGP 2:210477682-212538841
CIL_00083V CIL_00083V_0001 VISTA 2:211090115-211692433
CIL_0006PA CIL_0006PA_0001 CGP 2:211375717-213152427

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001755 ISS neural crest cell migration
GO:0001934 TAS positive regulation of protein phosphorylation
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0005154 IPI epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005739 IDA mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0007165 IDA signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 ISS nervous system development
GO:0007507 ISS heart development
GO:0007595 IMP lactation
GO:0008283 TAS cell proliferation
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009880 ISS embryonic pattern specification
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IDA basolateral plasma membrane
GO:0016477 IDA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0021551 ISS central nervous system morphogenesis
GO:0021889 ISS olfactory bulb interneuron differentiation
GO:0023014 IEA signal transduction by phosphorylation
GO:0030334 ISS regulation of cell migration
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042523 IMP positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042803 IPI protein homodimerization activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043235 IDA receptor complex
GO:0043552 IDA positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 IMP mitochondrial fragmentation involved in apoptotic process
GO:0044212 IMP transcription regulatory region DNA binding
GO:0045087 TAS innate immune response
GO:0045165 IEA cell fate commitment
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046777 IDA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060644 ISS mammary gland epithelial cell differentiation
GO:0060749 ISS mammary gland alveolus development
GO:0061026 ISS cardiac muscle tissue regeneration
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:2000366 IMP positive regulation of STAT protein import into nucleus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013847 egfra epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) protein_coding Danio_rerio
ENSDARG00000090408 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 protein_coding Danio_rerio
ENSMUSG00000062209 Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) protein_coding Mus_musculus

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