C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062209 Erbb4 10090 - 1:68032186-69108059 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000119142 Erbb4-002 68032186-69107756 protein_coding
  ENSMUST00000121473 Erbb4-001 68032186-69108059 protein_coding
  ENSMUST00000126682 Erbb4-003 68298150-68330216 retained_intron
  ENSMUST00000131148 Erbb4-005 68290155-68298318 processed_transcript
  ENSMUST00000153432 Erbb4-004 68250655-69107756 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000119142ENSMUST00000121473ENSMUST00000126682ENSMUST00000153432
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000119142 0.016±0.00 0.074±0.00 N/A 0.706±0.28 0.184±0.00 0.011±0.00 0.397±0.13 0.334±0.16 0.051±0.06 0.086±0.02 0.025±0.01 0.038±0.01 0.003±0.00 0.071±0.03
ENSMUST00000121473 0.029±0.00 0.079±0.03 0.029±0.00 1.756±0.39 0.135±0.06 N/A 0.211±0.00 0.937±0.30 0.126±0.08 0.084±0.03 N/A 0.094±0.05 0.000±0.00 0.055±0.00
ENSMUST00000126682 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.253±0.00 N/A N/A N/A N/A
ENSMUST00000153432 0.020±0.00 N/A N/A N/A N/A N/A 0.818±0.00 N/A 0.107±0.09 0.119±0.03 0.029±0.00 N/A N/A 0.091±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000164 CIL_000164_0002 CGP 1:67123026-69108059
CIL_00083V CIL_00083V_0002 VISTA 1:67745929-68348127
CIL_0006PA CIL_0006PA_0002 CGP 1:68032186-69687245

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001755 IMP neural crest cell migration
GO:0004714 ISS transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005739 IEA mitochondrion
GO:0006351 IEA transcription, DNA-templated
GO:0007165 IEA signal transduction
GO:0007169 ISS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IMP nervous system development
GO:0007507 IMP heart development
GO:0007595 IMP lactation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0009880 IMP embryonic pattern specification
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0016477 ISS cell migration
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0021551 IMP central nervous system morphogenesis
GO:0021889 IMP olfactory bulb interneuron differentiation
GO:0023014 IEA signal transduction by phosphorylation
GO:0030334 IMP regulation of cell migration
GO:0042523 IMP positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042803 IEA protein homodimerization activity
GO:0043066 ISS negative regulation of apoptotic process
GO:0043235 ISO receptor complex
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653 ISS mitochondrial fragmentation involved in apoptotic process
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045165 IDA cell fate commitment
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046777 ISS protein autophosphorylation
GO:0060045 IMP positive regulation of cardiac muscle cell proliferation
GO:0060644 IMP mammary gland epithelial cell differentiation
GO:0060749 IMP mammary gland alveolus development
GO:0061026 IMP cardiac muscle tissue regeneration
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:2000366 IMP positive regulation of STAT protein import into nucleus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013847 egfra epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) protein_coding Danio_rerio
ENSDARG00000090408 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 protein_coding Danio_rerio
ENSG00000178568 ERBB4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 protein_coding Homo_sapiens

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