C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calreticulin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000179218 CALR 9606 + 19:12938578-12944489 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316448 CALR-001 12938607-12944489 protein_coding
  ENST00000586760 CALR-006 12940397-12944403 protein_coding
  ENST00000586803 CALR-005 12943213-12943962 retained_intron
  ENST00000586967 CALR-007 12943873-12944489 nonsense_mediated_decay
  ENST00000587486 CALR-003 12938578-12940147 retained_intron
  ENST00000588454 CALR-008 12938645-12940872 protein_coding
  ENST00000590325 CALR-004 12938614-12940370 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316448ENST00000586760ENST00000586803
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316448 305.582±0.00 440.354±0.00 20.449±0.00 71.718±36.94 141.677±109.81 210.546±151.70 75.356±59.65 308.379±252.15 443.051±395.47 185.477±162.92 75.922±61.99 221.755±108.93 429.727±180.72 233.790±143.70
ENST00000586760 N/A N/A N/A 30.658±6.47 N/A 29.722±0.00 N/A N/A 31.408±0.00 N/A N/A 374.989±0.00 273.178±0.00 159.555±0.00
ENST00000586803 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 118.313±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VV CIL_0007VV_0001 VISTA 19:12752697-13356541
CIL_0007ZV CIL_0007ZV_0001 VISTA 19:12767682-13372012

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001669 IEA acrosomal vesicle
GO:0001849 TAS complement component C1q binding
GO:0001948 IPI glycoprotein binding
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002502 ISS peptide antigen assembly with MHC class I protein complex
GO:0003677 NAS DNA binding
GO:0003729 IDA mRNA binding
GO:0005178 IPI integrin binding
GO:0005506 IEA iron ion binding
GO:0005509 ISS:IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005622 TAS intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005783 TAS:IEA endoplasmic reticulum
GO:0005788 IDA endoplasmic reticulum lumen
GO:0005790 IEA smooth endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005844 ISS polysome
GO:0005925 IDA focal adhesion
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006457 TAS:IEA protein folding
GO:0006611 IDA protein export from nucleus
GO:0006874 TAS cellular calcium ion homeostasis
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007050 IGI cell cycle arrest
GO:0007283 IEA spermatogenesis
GO:0008270 TAS zinc ion binding
GO:0008284 IGI positive regulation of cell proliferation
GO:0009897 IEA external side of plasma membrane
GO:0009986 TAS cell surface
GO:0010033 IEA response to organic substance
GO:0010628 IEA positive regulation of gene expression
GO:0016020 IDA membrane
GO:0016529 IEA sarcoplasmic reticulum
GO:0017148 TAS negative regulation of translation
GO:0018279 TAS protein N-linked glycosylation via asparagine
GO:0022417 TAS protein maturation by protein folding
GO:0030246 TAS carbohydrate binding
GO:0030866 IEA cortical actin cytoskeleton organization
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0031012 IEA extracellular matrix
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032355 IEA response to estradiol
GO:0033144 IDA negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033574 IEA response to testosterone
GO:0034504 IDA protein localization to nucleus
GO:0040020 IEA regulation of meiosis
GO:0042277 IEA peptide binding
GO:0042493 IEA response to drug
GO:0042562 IEA hormone binding
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042824 ISS MHC class I peptide loading complex
GO:0042921 TAS glucocorticoid receptor signaling pathway
GO:0042981 TAS regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043687 TAS post-translational protein modification
GO:0044183 TAS protein binding involved in protein folding
GO:0044267 TAS cellular protein metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0045665 IDA negative regulation of neuron differentiation
GO:0045740 IGI positive regulation of DNA replication
GO:0045787 IGI positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0048387 IDA negative regulation of retinoic acid receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050681 IDA androgen receptor binding
GO:0050766 ISS positive regulation of phagocytosis
GO:0050821 ISS protein stabilization
GO:0051082 TAS:IEA unfolded protein binding
GO:0051087 TAS chaperone binding
GO:0051208 TAS sequestering of calcium ion
GO:0055007 IEA cardiac muscle cell differentiation
GO:0061077 IEA chaperone-mediated protein folding
GO:0070062 IDA extracellular vesicular exosome
GO:0071285 IEA cellular response to lithium ion
GO:0071310 IEA cellular response to organic substance
GO:0071556 TAS integral component of lumenal side of endoplasmic reticulum membrane
GO:0071682 TAS endocytic vesicle lumen
GO:0090398 IGI cellular senescence
GO:1900026 IMP positive regulation of substrate adhesion-dependent cell spreading
GO:2000510 IMP positive regulation of dendritic cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076290 calrl2 calreticulin, like 2 protein_coding Danio_rerio
ENSMUSG00000003814 Calr calreticulin protein_coding Mus_musculus

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