C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: beta-site APP-cleaving enzyme 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182240 BACE2 9606 + 21:41167801-41282518 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000328735 BACE2-003 41167801-41276597 protein_coding
  ENST00000330333 BACE2-001 41167801-41276597 protein_coding
  ENST00000347667 BACE2-002 41167801-41282518 protein_coding
  ENST00000463674 BACE2-008 41241745-41275624 processed_transcript
  ENST00000465326 BACE2-006 41236628-41257326 processed_transcript
  ENST00000466122 BACE2-004 41230118-41276597 processed_transcript
  ENST00000470864 BACE2-005 41225476-41241839 processed_transcript
  ENST00000475618 BACE2-010 41252465-41257326 processed_transcript
  ENST00000487994 BACE2-007 41226266-41275381 processed_transcript
  ENST00000491838 BACE2-009 41226303-41246271 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000328735ENST00000330333ENST00000347667ENST00000463674ENST00000466122ENST00000487994ENST00000491838
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000328735 N/A N/A N/A N/A N/A 6.385±0.00 0.692±0.00 0.172±0.00 1.146±0.00 N/A 0.312±0.00 9.861±1.76 11.132±0.00 N/A
ENST00000330333 9.693±0.00 20.260±0.00 4.570±0.00 1.494±0.00 7.312±0.87 10.710±0.00 3.219±0.00 9.765±0.00 1.034±0.00 6.626±4.68 1.702±0.00 6.203±0.54 11.967±2.80 5.531±0.00
ENST00000347667 N/A N/A 0.427±0.00 N/A N/A N/A 0.263±0.00 N/A N/A 0.915±0.00 0.043±0.00 1.418±0.42 N/A 0.263±0.00
ENST00000463674 N/A N/A N/A 1.317±0.00 N/A 13.994±0.00 N/A N/A N/A 11.238±0.00 N/A 41.347±0.00 25.511±15.18 5.190±0.00
ENST00000466122 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.434±0.00 N/A
ENST00000487994 N/A N/A N/A N/A N/A N/A N/A N/A 2.459±0.00 N/A 1.563±0.00 N/A N/A 1.156±0.00
ENST00000491838 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.771±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CW CIL_0001CW_0002 CGP 21:40010999-41282518

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004190 IDA:IEA aspartic-type endopeptidase activity
GO:0005768 IEA endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0006508 NAS:IEA proteolysis
GO:0006509 IDA membrane protein ectodomain proteolysis
GO:0016021 NAS integral component of membrane
GO:0016486 NAS peptide hormone processing
GO:0042985 IMP negative regulation of amyloid precursor protein biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044781 bace2 beta-site APP-cleaving enzyme 2 protein_coding Danio_rerio
ENSDARG00000086067 BACE2 (2 of 2) beta-site APP-cleaving enzyme 2 protein_coding Danio_rerio
ENSMUSG00000040605 Bace2 beta-site APP-cleaving enzyme 2 protein_coding Mus_musculus

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