C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phospholipase C, beta 1 (phosphoinositide-specific)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000378641 PLCB1-005 ENSG00000182621 9606 + 20:8132177-8884900 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaENST00000378641
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000378641 1.345±0.00 0.344±0.00 0.914±0.00 5.582±1.26 1.322±0.76 0.577±0.00 2.165±0.00 1.752±0.00 1.087±0.35 0.580±0.06 1.841±0.68 0.658±0.29

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006F4 CIL_0006F4_0001 CGP 20:7977348-8968356
CIL_0001PB CIL_0001PB_0001 CGP 20:8132177-9481242

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000086 ISS G2/M transition of mitotic cell cycle
GO:0000790 ISS nuclear chromatin
GO:0004435 ISS:IEA phosphatidylinositol phospholipase C activity
GO:0004871 IEA signal transducer activity
GO:0005096 IDA GTPase activator activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005516 IPI calmodulin binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 NAS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006629 IEA lipid metabolic process
GO:0007165 NAS:IEA signal transduction
GO:0007213 ISS G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 ISS glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007613 ISS memory
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0008277 ISS regulation of G-protein coupled receptor protein signaling pathway
GO:0016020 IEA membrane
GO:0016042 IEA lipid catabolic process
GO:0016607 IDA nuclear speck
GO:0019899 IPI enzyme binding
GO:0021987 ISS cerebral cortex development
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0035556 IEA intracellular signal transduction
GO:0035722 IDA interleukin-12-mediated signaling pathway
GO:0035723 IDA interleukin-15-mediated signaling pathway
GO:0040019 ISS positive regulation of embryonic development
GO:0042803 ISS protein homodimerization activity
GO:0043547 IDA positive regulation of GTPase activity
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045663 ISS positive regulation of myoblast differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046330 IDA positive regulation of JNK cascade
GO:0046488 ISS phosphatidylinositol metabolic process
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0048639 ISS positive regulation of developmental growth
GO:0060466 ISS activation of meiosis involved in egg activation
GO:0070062 IDA extracellular vesicular exosome
GO:0070498 IDA interleukin-1-mediated signaling pathway
GO:0080154 ISS regulation of fertilization
GO:1900087 ISS positive regulation of G1/S transition of mitotic cell cycle
GO:2000344 ISS positive regulation of acrosome reaction
GO:2000438 ISS negative regulation of monocyte extravasation
GO:2000560 ISS positive regulation of CD24 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110116 Plcb1-001 protein_coding Mus_musculus 0 4490
ENSMUST00000070724 Plcb1-003 protein_coding Mus_musculus 0 4468
ENSMUST00000131552 Plcb1-005 protein_coding Mus_musculus 0 861
ENSMUST00000130524 Plcb1-004 retained_intron Mus_musculus 0 551
ENSMUST00000129382 Plcb1-002 processed_transcript Mus_musculus 0 440

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