C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: LCK proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000182866 LCK 9606 + 1:32251239-32286165 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333070 LCK-004 32274132-32286162 protein_coding
  ENST00000336890 LCK-001 32251239-32286165 protein_coding
  ENST00000355928 LCK-014 32251275-32275255 retained_intron
  ENST00000373557 LCK-010 32274121-32276428 protein_coding
  ENST00000373562 LCK-013 32274115-32275604 protein_coding
  ENST00000373564 LCK-201 32251239-32286164 protein_coding
  ENST00000461712 LCK-012 32274113-32275078 protein_coding
  ENST00000469765 LCK-007 32251318-32286160 retained_intron
  ENST00000469956 LCK-003 32275620-32277173 retained_intron
  ENST00000476457 LCK-009 32251298-32275446 retained_intron
  ENST00000477031 LCK-011 32274121-32275002 protein_coding
  ENST00000482949 LCK-002 32251264-32275618 protein_coding
  ENST00000495610 LCK-006 32251274-32279909 protein_coding
  ENST00000619559 LCK-202 32274111-32286164 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000333070ENST00000336890ENST00000355928ENST00000373557ENST00000373564ENST00000461712ENST00000469765ENST00000469956ENST00000482949ENST00000495610ENST00000619559
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000333070 N/A N/A N/A N/A N/A N/A 0.161±0.00 N/A N/A 1.512±0.62 N/A N/A N/A N/A
ENST00000336890 0.109±0.00 22.698±0.00 N/A 0.062±0.00 0.713±0.54 N/A N/A 0.876±0.00 0.658±0.00 9.313±0.00 N/A 1.973±0.14 0.668±0.33 1.030±0.00
ENST00000355928 N/A N/A 0.480±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000373557 N/A N/A N/A 0.056±0.00 N/A 0.471±0.00 N/A N/A 1.225±0.00 N/A N/A N/A N/A N/A
ENST00000373564 N/A N/A N/A N/A N/A N/A 0.088±0.00 N/A N/A N/A N/A N/A N/A 0.201±0.00
ENST00000461712 N/A N/A N/A N/A N/A N/A N/A N/A 0.681±0.00 N/A N/A N/A N/A N/A
ENST00000469765 N/A N/A N/A N/A 0.350±0.00 N/A 0.108±0.00 N/A N/A N/A N/A 1.072±0.00 N/A N/A
ENST00000469956 0.279±0.00 N/A N/A 0.278±0.00 N/A 0.463±0.00 0.097±0.00 0.694±0.52 N/A N/A 0.092±0.00 N/A N/A 0.420±0.22
ENST00000482949 N/A N/A N/A N/A N/A 0.665±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000495610 N/A N/A N/A N/A 0.328±0.00 1.098±0.00 N/A N/A N/A N/A N/A N/A N/A 0.255±0.00
ENST00000619559 N/A N/A N/A N/A N/A N/A N/A 0.290±0.01 0.265±0.00 1.418±0.00 0.307±0.00 6.511±3.47 0.442±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AA CIL_0008AA_0001 VISTA 1:31744429-32345312

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000242 ISS pericentriolar material
GO:0001772 IDA immunological synapse
GO:0001948 IPI glycoprotein binding
GO:0003823 IEA antigen binding
GO:0004672 IEA protein kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0004722 ISS protein serine/threonine phosphatase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0006882 ISS cellular zinc ion homeostasis
GO:0006915 IEA apoptotic process
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008022 IPI protein C-terminus binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009612 IEA response to mechanical stimulus
GO:0010038 IEA response to metal ion
GO:0010043 IEA response to zinc ion
GO:0010628 IEA positive regulation of gene expression
GO:0016032 TAS viral process
GO:0016311 ISS dephosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0030097 NAS hemopoiesis
GO:0030139 IEA endocytic vesicle
GO:0030168 TAS platelet activation
GO:0030217 ISS T cell differentiation
GO:0031295 TAS T cell costimulation
GO:0032403 IEA protein complex binding
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042169 ISS SH2 domain binding
GO:0042493 ISS response to drug
GO:0042523 IEA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542 IEA response to hydrogen peroxide
GO:0042609 IPI CD4 receptor binding
GO:0042610 IPI CD8 receptor binding
GO:0042802 IPI identical protein binding
GO:0043548 IPI phosphatidylinositol 3-kinase binding
GO:0045087 TAS innate immune response
GO:0045121 ISS membrane raft
GO:0045588 IEA positive regulation of gamma-delta T cell differentiation
GO:0046777 IEA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050852 TAS T cell receptor signaling pathway
GO:0050853 IEA B cell receptor signaling pathway
GO:0050856 IEA regulation of T cell receptor signaling pathway
GO:0050862 NAS positive regulation of T cell receptor signaling pathway
GO:0050870 ISS positive regulation of T cell activation
GO:0050900 TAS leukocyte migration
GO:0051117 IPI ATPase binding
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0051249 NAS regulation of lymphocyte activation
GO:0070062 IDA extracellular vesicular exosome
GO:0070474 IEA positive regulation of uterine smooth muscle contraction
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059282 lck lymphocyte-specific protein tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000000409 Lck lymphocyte protein tyrosine kinase protein_coding Mus_musculus

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