C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lymphocyte protein tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000409 Lck 10090 - 4:129548344-129573641 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067240 Lck-002 129548349-129558391 protein_coding
  ENSMUST00000102596 Lck-001 129548349-129573641 protein_coding
  ENSMUST00000123640 Lck-004 129555476-129556459 retained_intron
  ENSMUST00000127943 Lck-005 129551976-129556231 retained_intron
  ENSMUST00000132030 Lck-007 129548895-129555848 retained_intron
  ENSMUST00000134336 Lck-003 129557365-129558372 protein_coding
  ENSMUST00000139957 Lck-006 129556863-129558087 retained_intron
  ENSMUST00000167288 Lck-201 129548344-129558372 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000067240ENSMUST00000102596ENSMUST00000123640ENSMUST00000132030ENSMUST00000139957ENSMUST00000167288
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000067240 0.269±0.00 0.306±0.00 N/A N/A 3.763±0.00 N/A N/A 0.168±0.00 0.487±0.07 0.935±0.33 N/A 0.363±0.00 N/A
ENSMUST00000102596 1.688±0.92 0.279±0.00 1.067±0.33 0.159±0.00 30.916±14.32 1.663±0.90 0.586±0.24 2.970±2.19 0.545±0.33 3.821±0.64 1.745±1.74 0.743±0.30 0.452±0.00
ENSMUST00000123640 N/A 0.808±0.00 N/A 0.696±0.00 N/A N/A N/A N/A 0.477±0.00 N/A 0.054±0.00 N/A N/A
ENSMUST00000132030 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.046±0.00 1.540±0.00 1.254±0.70
ENSMUST00000139957 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.263±0.00
ENSMUST00000167288 1.268±0.00 0.827±0.07 N/A N/A 13.320±0.00 0.663±0.00 0.125±0.08 0.279±0.00 0.847±0.45 N/A 0.043±0.01 N/A 0.263±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AA CIL_0008AA_0002 VISTA 4:129413466-130014337

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000242 ISS pericentriolar material
GO:0001772 IEA immunological synapse
GO:0001948 IEA glycoprotein binding
GO:0003823 IEA antigen binding
GO:0004713 IMP:ISS protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0004722 ISS protein serine/threonine phosphatase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IDA protein phosphorylation
GO:0006882 ISS cellular zinc ion homeostasis
GO:0006915 IEA apoptotic process
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007568 IEA aging
GO:0008022 IEA protein C-terminus binding
GO:0009612 IEA response to mechanical stimulus
GO:0010038 IEA response to metal ion
GO:0010043 IEA response to zinc ion
GO:0010628 IDA positive regulation of gene expression
GO:0016311 ISS dephosphorylation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0030139 IEA endocytic vesicle
GO:0030217 ISS T cell differentiation
GO:0032403 IEA protein complex binding
GO:0042169 ISS SH2 domain binding
GO:0042493 ISS response to drug
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542 IEA response to hydrogen peroxide
GO:0042609 IEA CD4 receptor binding
GO:0042610 IEA CD8 receptor binding
GO:0042802 IEA identical protein binding
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0045121 ISS membrane raft
GO:0045588 IMP positive regulation of gamma-delta T cell differentiation
GO:0046777 IDA protein autophosphorylation
GO:0050853 IDA B cell receptor signaling pathway
GO:0050856 IDA regulation of T cell receptor signaling pathway
GO:0050870 ISS positive regulation of T cell activation
GO:0051117 IEA ATPase binding
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0070062 IEA extracellular vesicular exosome
GO:0070474 IEA positive regulation of uterine smooth muscle contraction
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059282 lck lymphocyte-specific protein tyrosine kinase protein_coding Danio_rerio
ENSG00000182866 LCK LCK proto-oncogene, Src family tyrosine kinase protein_coding Homo_sapiens

Loading