C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ArfGAP with dual PH domains 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184060 ADAP2 9606 + 17:30906344-30959322 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000330889 ADAP2-001 30921680-30959322 protein_coding
  ENST00000470962 ADAP2-002 30954254-30958141 retained_intron
  ENST00000480980 ADAP2-003 30954240-30956728 retained_intron
  ENST00000580525 ADAP2-005 30921932-30958220 protein_coding
  ENST00000580526 ADAP2-009 30921948-30949330 nonsense_mediated_decay
  ENST00000581285 ADAP2-008 30921935-30956442 protein_coding
  ENST00000581548 ADAP2-007 30921917-30949338 protein_coding
  ENST00000583688 ADAP2-006 30906344-30921760 processed_transcript
  ENST00000584828 ADAP2-010 30945028-30958339 protein_coding
  ENST00000584989 ADAP2-011 30945042-30956362 protein_coding
  ENST00000585130 ADAP2-004 30921680-30958739 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000330889ENST00000580525ENST00000580526ENST00000581285ENST00000581548
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000330889 2.398±0.00 4.785±0.00 1.515±0.00 2.508±0.47 1.155±0.31 3.741±0.00 1.695±0.00 1.830±1.24 0.248±0.00 1.740±0.44 8.023±0.76 1.514±0.00
ENST00000580525 2.921±0.00 N/A N/A N/A N/A N/A N/A 3.085±0.00 N/A N/A N/A N/A
ENST00000580526 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.240±0.00 N/A
ENST00000581285 N/A N/A N/A 2.248±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000581548 N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.492±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004GS CIL_0004GS_0002 CGP 17:30831970-30906820
CIL_000740 CIL_000740_0001 CGP 17:30897336-30959322
CIL_00073Y CIL_00073Y_0001 CGP 17:30906344-30999911

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005546 ISS phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005737 IDA cytoplasm
GO:0005740 ISS mitochondrial envelope
GO:0005886 IDA plasma membrane
GO:0007507 IEP heart development
GO:0008060 IEA ARF GTPase activator activity
GO:0008270 IEA zinc ion binding
GO:0030674 NAS protein binding, bridging
GO:0032312 IEA regulation of ARF GTPase activity
GO:0043325 ISS phosphatidylinositol-3,4-bisphosphate binding
GO:0043533 IDA inositol 1,3,4,5 tetrakisphosphate binding
GO:0043547 IEA positive regulation of GTPase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070565 ADAP2 ArfGAP with dual PH domains 2 protein_coding Danio_rerio
ENSMUSG00000020709 Adap2 ArfGAP with dual PH domains 2 protein_coding Mus_musculus

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