C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase A2, group VI (cytosolic, calcium-independent)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184381 PLA2G6 9606 - 22:38111495-38205690 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332509 PLA2G6-001 38111495-38181802 protein_coding
  ENST00000335539 PLA2G6-201 38111496-38181754 protein_coding
  ENST00000402064 PLA2G6-002 38111500-38181829 protein_coding
  ENST00000417303 PLA2G6-005 38145606-38192100 protein_coding
  ENST00000420435 PLA2G6-004 38147368-38181829 processed_transcript
  ENST00000426674 PLA2G6-006 38147379-38181783 processed_transcript
  ENST00000427114 PLA2G6-016 38128343-38145464 protein_coding
  ENST00000427453 PLA2G6-018 38129518-38140033 protein_coding
  ENST00000430886 PLA2G6-014 38140065-38181780 protein_coding
  ENST00000435484 PLA2G6-003 38145592-38181828 protein_coding
  ENST00000436218 PLA2G6-012 38140135-38181830 protein_coding
  ENST00000445591 PLA2G6-011 38143229-38163672 processed_transcript
  ENST00000447598 PLA2G6-010 38145493-38181808 protein_coding
  ENST00000448094 PLA2G6-023 38116094-38135063 nonsense_mediated_decay
  ENST00000452542 PLA2G6-017 38129541-38143214 protein_coding
  ENST00000452794 PLA2G6-019 38126996-38132877 protein_coding
  ENST00000452972 PLA2G6-008 38143237-38168090 processed_transcript
  ENST00000454670 PLA2G6-026 38115556-38126442 nonsense_mediated_decay
  ENST00000455341 PLA2G6-007 38145624-38180404 protein_coding
  ENST00000463287 PLA2G6-025 38111872-38112855 retained_intron
  ENST00000471636 PLA2G6-013 38126371-38181814 retained_intron
  ENST00000479641 PLA2G6-009 38140134-38168077 processed_transcript
  ENST00000480154 PLA2G6-020 38128161-38129506 retained_intron
  ENST00000490473 PLA2G6-021 38123204-38127228 processed_transcript
  ENST00000491986 PLA2G6-022 38120759-38126755 retained_intron
  ENST00000496409 PLA2G6-024 38113538-38121040 retained_intron
  ENST00000498338 PLA2G6-015 38134988-38143494 protein_coding
  ENST00000594306 PLA2G6-027 38169275-38205690 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000332509ENST00000402064ENST00000420435ENST00000448094ENST00000452972ENST00000454670ENST00000463287ENST00000479641ENST00000480154ENST00000490473ENST00000491986ENST00000496409
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000332509 1.540±0.00 N/A 2.361±1.49 1.095±0.87 0.649±0.00 N/A 0.137±0.00 N/A N/A N/A N/A N/A 10.083±0.25
ENST00000402064 N/A 0.497±0.00 2.918±2.22 3.020±0.00 1.029±0.00 1.163±0.00 1.751±0.00 0.541±0.00 N/A 1.966±1.50 5.324±3.74 0.616±0.20 N/A
ENST00000420435 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.945±0.00 N/A N/A N/A
ENST00000448094 N/A N/A N/A N/A 1.094±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000452972 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.887±0.00 N/A N/A
ENST00000454670 N/A N/A N/A N/A N/A N/A N/A N/A 3.210±0.00 N/A N/A 1.550±0.02 N/A
ENST00000463287 N/A N/A N/A N/A N/A N/A 5.114±0.00 N/A N/A N/A N/A N/A N/A
ENST00000479641 N/A N/A N/A N/A N/A 1.045±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000480154 N/A N/A N/A 3.598±0.00 5.321±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000490473 N/A N/A N/A N/A N/A N/A 3.841±0.00 N/A 2.832±0.00 N/A 10.970±7.19 N/A N/A
ENST00000491986 N/A N/A N/A N/A 1.655±0.00 N/A 0.956±0.00 N/A N/A N/A N/A N/A N/A
ENST00000496409 N/A 2.499±0.00 N/A N/A N/A N/A 0.728±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00099H CIL_00099H_0001 VISTA 22:37683926-38284300
CIL_0008KJ CIL_0008KJ_0001 VISTA 22:37685616-38286450
CIL_0008BX CIL_0008BX_0001 VISTA 22:37696030-38296592
CIL_0008KA CIL_0008KA_0001 VISTA 22:37698338-38299192
CIL_00082J CIL_00082J_0001 VISTA 22:37733233-38334508
CIL_0008C1 CIL_0008C1_0001 VISTA 22:37746133-38346872
CIL_00082K CIL_00082K_0001 VISTA 22:37750385-38350990
CIL_0008MM CIL_0008MM_0001 VISTA 22:37872841-38473542
CIL_0007CL CIL_0007CL_0001 CGP 22:38084889-38205690
CIL_0003QB CIL_0003QB_0001 CGP 22:38111495-38216511

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004623 TAS phospholipase A2 activity
GO:0005515 IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006629 IEA lipid metabolic process
GO:0006644 TAS phospholipid metabolic process
GO:0006935 IEA chemotaxis
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007613 IEA memory
GO:0008152 IEA metabolic process
GO:0008219 IEA cell death
GO:0014832 IEA urinary bladder smooth muscle contraction
GO:0016020 IEA membrane
GO:0016042 IEA lipid catabolic process
GO:0032049 IMP cardiolipin biosynthetic process
GO:0034976 IEA response to endoplasmic reticulum stress
GO:0035774 IEA positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035965 TAS cardiolipin acyl-chain remodeling
GO:0036151 TAS phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS phosphatidylethanolamine acyl-chain remodeling
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043008 IEA ATP-dependent protein binding
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045909 IEA positive regulation of vasodilation
GO:0045921 IEA positive regulation of exocytosis
GO:0046474 TAS glycerophospholipid biosynthetic process
GO:0047499 IEA calcium-independent phospholipase A2 activity
GO:0051967 IEA negative regulation of synaptic transmission, glutamatergic
GO:0060135 IEA maternal process involved in female pregnancy
GO:0090037 IEA positive regulation of protein kinase C signaling
GO:0090200 IEA positive regulation of release of cytochrome c from mitochondria
GO:0090238 IEA positive regulation of arachidonic acid secretion
GO:1901339 IEA regulation of store-operated calcium channel activity
GO:2000304 IEA positive regulation of ceramide biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060921 pla2g6 phospholipase A2, group VI (cytosolic, calcium-independent) protein_coding Danio_rerio
ENSMUSG00000042632 Pla2g6 phospholipase A2, group VI protein_coding Mus_musculus

Loading