C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase A2, group VI
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000042632 Pla2g6 10090 - 15:79286228-79328390 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000047816 Pla2g6-003 79286228-79328228 protein_coding
  ENSMUST00000166977 Pla2g6-002 79286228-79328176 protein_coding
  ENSMUST00000172403 Pla2g6-001 79286232-79328253 protein_coding
  ENSMUST00000172936 Pla2g6-007 79317871-79324488 protein_coding
  ENSMUST00000173109 Pla2g6-008 79311806-79323566 protein_coding
  ENSMUST00000173163 Pla2g6-004 79286228-79328203 protein_coding
  ENSMUST00000173412 Pla2g6-012 79303009-79305715 retained_intron
  ENSMUST00000173601 Pla2g6-010 79305671-79308797 retained_intron
  ENSMUST00000173632 Pla2g6-006 79308854-79328390 protein_coding
  ENSMUST00000174021 Pla2g6-005 79286228-79327964 protein_coding
  ENSMUST00000174089 Pla2g6-011 79311738-79318012 retained_intron
  ENSMUST00000174375 Pla2g6-009 79289171-79304492 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000047816ENSMUST00000166977ENSMUST00000172403ENSMUST00000173163ENSMUST00000174021
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000047816 N/A N/A N/A N/A N/A 1.041±0.00 0.762±0.00 1.936±0.00 2.120±0.26 N/A 1.854±0.00 3.442±0.00 2.687±0.31 N/A
ENSMUST00000166977 8.112±0.74 12.748±0.78 6.899±0.27 3.756±0.91 9.220±3.58 2.166±0.64 1.913±0.28 5.439±0.60 5.485±1.40 6.508±0.60 2.261±0.76 11.639±4.26 10.216±6.21 16.585±1.20
ENSMUST00000172403 6.014±1.79 N/A N/A N/A N/A 1.287±0.37 1.177±0.21 N/A 2.162±0.32 N/A 1.852±0.58 3.223±0.00 N/A 30.832±7.61
ENSMUST00000173163 2.448±0.58 2.600±0.00 N/A N/A N/A 1.147±0.00 0.670±0.05 1.198±0.00 1.674±0.51 1.796±0.00 2.513±1.05 2.823±0.00 1.844±0.00 N/A
ENSMUST00000174021 4.362±1.62 4.767±1.06 1.809±0.17 4.052±2.00 5.666±0.99 1.208±0.29 0.479±0.00 2.408±0.56 2.100±0.48 2.176±0.46 0.994±0.22 3.702±1.42 4.038±2.26 47.289±24.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00099H CIL_00099H_0002 VISTA 15:78863840-79464236
CIL_0008KJ CIL_0008KJ_0002 VISTA 15:78865517-79466323
CIL_0008BX CIL_0008BX_0002 VISTA 15:78873761-79474273
CIL_0008KA CIL_0008KA_0002 VISTA 15:78875821-79476550
CIL_00082J CIL_00082J_0002 VISTA 15:78908803-79509777
CIL_0008C1 CIL_0008C1_0002 VISTA 15:78918952-79520098
CIL_00082K CIL_00082K_0002 VISTA 15:78923635-79524085
CIL_0008MM CIL_0008MM_0002 VISTA 15:79023554-79624112
CIL_0007CL CIL_0007CL_0002 CGP 15:79258195-79328390
CIL_0003QB CIL_0003QB_0002 CGP 15:79286228-79359072

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0005516 IEA calmodulin binding
GO:0005739 IEA mitochondrion
GO:0005829 IEA cytosol
GO:0006935 IEA chemotaxis
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007613 IEA memory
GO:0014832 IEA urinary bladder smooth muscle contraction
GO:0016020 IEA membrane
GO:0016042 IEA lipid catabolic process
GO:0032049 IEA cardiolipin biosynthetic process
GO:0034976 IEA response to endoplasmic reticulum stress
GO:0035774 IEA positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043008 IEA ATP-dependent protein binding
GO:0045909 IEA positive regulation of vasodilation
GO:0045921 IEA positive regulation of exocytosis
GO:0047499 IEA calcium-independent phospholipase A2 activity
GO:0051967 IEA negative regulation of synaptic transmission, glutamatergic
GO:0060135 IEA maternal process involved in female pregnancy
GO:0090037 IEA positive regulation of protein kinase C signaling
GO:0090200 IEA positive regulation of release of cytochrome c from mitochondria
GO:0090238 IEA positive regulation of arachidonic acid secretion
GO:1901339 IEA regulation of store-operated calcium channel activity
GO:2000304 IEA positive regulation of ceramide biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060921 pla2g6 phospholipase A2, group VI (cytosolic, calcium-independent) protein_coding Danio_rerio
ENSG00000184381 PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) protein_coding Homo_sapiens

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