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                ),
                E_USER_WARNING
            );
$key = 'cake_dev_eng'
$value = array(
	'LC_MESSAGES' => array()
)
$config = '_cake_core_'
$settings = array(
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	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
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$key = 'default_citloci_list'
$value = null
$config = '_cake_model_'
$settings = array(
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	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
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$key = 'default_citloci_list'
$value = array(
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	(int) 2 => 'diffexp',
	(int) 3 => 'experiment',
	(int) 4 => 'expressed_transcripts',
	(int) 5 => 'external_accessions',
	(int) 6 => 'genes',
	(int) 7 => 'go_annotations',
	(int) 8 => 'homologues',
	(int) 9 => 'maptranscripttoregion',
	(int) 10 => 'organism',
	(int) 11 => 'sample',
	(int) 12 => 'study',
	(int) 13 => 'synonyms',
	(int) 14 => 'transcripts'
)
$config = '_cake_model_'
$settings = array(
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	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_genes'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

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                ),
                E_USER_WARNING
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$config = '_cake_model_'
$settings = array(
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	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
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$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

• HOME
• REGIONS
• GENES
• TRANSCRIPTS
• HELP
• CONTACT

Gene Info
Description:	suppressor of cytokine signaling 3
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000184557	SOCS3	9606	-	17:78356778-78360077	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000330871		SOCS3-001	78356778-78360077	protein_coding
	ENST00000587578		SOCS3-002	78359049-78360074	protein_coding

Expression Patterns Heat Map Numeric Values Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis ENST00000330871 41.031±0.00 73.118±0.00 2.631±0.00 5.881±4.30 20.407±0.91 22.804±18.35 5.058±4.49 5.461±4.89 24.234±6.91 90.081±80.56 11.590±0.51 61.442±59.29 25.888±4.30 8.735±8.03

Conserved Regions
Region ID	Sub-Region	Region Type	Position
CIL_0007YS	CIL_0007YS_0001	VISTA	17:77940736-78544976
CIL_0003UD	CIL_0003UD_0002	CGP	17:78356778-78425114

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0001932	IEA	regulation of protein phosphorylation
GO:0004860	TAS	protein kinase inhibitor activity
GO:0005515	IPI	protein binding
GO:0005829	TAS	cytosol
GO:0006469	TAS	negative regulation of protein kinase activity
GO:0007259	TAS	JAK-STAT cascade
GO:0009968	IEA	negative regulation of signal transduction
GO:0016567	IEA	protein ubiquitination
GO:0019221	TAS	cytokine-mediated signaling pathway
GO:0035556	IEA	intracellular signal transduction
GO:0040008	IEA	regulation of growth
GO:0043066	IEA	negative regulation of apoptotic process
GO:0045595	IEA	regulation of cell differentiation
GO:0045597	IEA	positive regulation of cell differentiation
GO:0046627	IEA	negative regulation of insulin receptor signaling pathway
GO:0050728	IEA	negative regulation of inflammatory response
GO:0060333	TAS	interferon-gamma-mediated signaling pathway
GO:0060334	TAS	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	TAS	type I interferon signaling pathway
GO:0060338	TAS	regulation of type I interferon-mediated signaling pathway
GO:0060397	TAS	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060670	IEA	branching involved in labyrinthine layer morphogenesis
GO:0060674	IEA	placenta blood vessel development
GO:0060707	IEA	trophoblast giant cell differentiation
GO:0060708	IEA	spongiotrophoblast differentiation

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000025428	socs3a	suppressor of cytokine signaling 3a	protein_coding	Danio_rerio
ENSDARG00000026611	socs3b	suppressor of cytokine signaling 3b	protein_coding	Danio_rerio
ENSMUSG00000053113	Socs3	suppressor of cytokine signaling 3	protein_coding	Mus_musculus

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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

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			(int) 1 => '`Gene`.`gene_version`',
			(int) 2 => '`Gene`.`tax_id`',
			(int) 3 => '`Gene`.`assembly`',
			(int) 4 => '`Gene`.`chromosome`',
			(int) 5 => '`Gene`.`strand`',
			(int) 6 => '`Gene`.`start`',
			(int) 7 => '`Gene`.`end`',
			(int) 8 => '`Gene`.`gene_name`',
			(int) 9 => '`Gene`.`gene_source`',
			(int) 10 => '`Gene`.`gene_biotype`',
			(int) 11 => '`Gene`.`annotation_version`',
			(int) 12 => '`Gene`.`gene_description`'
		)
	)
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??