C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 4B, cAMP-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184588 PDE4B 9606 + 1:65792514-66374579 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329654 PDE4B-001 65792514-66374278 protein_coding
  ENST00000341517 PDE4B-002 65793181-66373504 protein_coding
  ENST00000371045 PDE4B-007 66332004-66374579 protein_coding
  ENST00000371048 PDE4B-004 66257365-66267509 processed_transcript
  ENST00000412480 PDE4B-014 66152390-66332590 protein_coding
  ENST00000423207 PDE4B-003 65992422-66374573 protein_coding
  ENST00000480109 PDE4B-008 66354382-66372738 protein_coding
  ENST00000483863 PDE4B-018 66367494-66368157 retained_intron
  ENST00000490695 PDE4B-005 66257425-66267139 processed_transcript
  ENST00000491340 PDE4B-006 66257647-66266155 protein_coding
  ENST00000524999 PDE4B-016 66360426-66363242 processed_transcript
  ENST00000526197 PDE4B-011 66332189-66363260 protein_coding
  ENST00000526666 PDE4B-013 65992736-66247544 processed_transcript
  ENST00000528771 PDE4B-009 66330728-66363215 protein_coding
  ENST00000531025 PDE4B-010 66332149-66363234 protein_coding
  ENST00000531358 PDE4B-017 65992616-66112798 processed_transcript
  ENST00000532040 PDE4B-012 65992735-66247557 processed_transcript
  ENST00000534463 PDE4B-015 66355125-66363498 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000329654ENST00000341517ENST00000371045ENST00000423207ENST00000480109ENST00000526197ENST00000534463
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000329654 N/A N/A N/A N/A N/A 1.174±0.00 N/A N/A N/A N/A N/A N/A 2.008±0.00 N/A
ENST00000341517 N/A N/A N/A 7.197±0.00 1.700±0.00 N/A N/A 0.224±0.00 N/A N/A 1.097±0.00 N/A N/A N/A
ENST00000371045 2.959±0.00 1.894±0.00 N/A 4.267±1.62 2.360±0.12 1.105±0.10 0.426±0.07 0.202±0.03 0.938±0.78 6.868±0.64 1.409±0.67 0.839±0.29 1.326±0.27 1.020±0.00
ENST00000423207 N/A N/A N/A 3.833±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.011±0.00 N/A
ENST00000480109 N/A N/A 1.292±0.00 N/A N/A N/A N/A N/A 1.167±0.00 5.027±0.00 N/A 0.290±0.00 N/A N/A
ENST00000526197 N/A N/A N/A N/A N/A N/A 1.270±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000534463 N/A N/A 1.407±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002NS CIL_0002NS_0001 CGP 1:65792514-66748299

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001780 ISS neutrophil homeostasis
GO:0004114 ISS:IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005891 ISS voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0007165 IEA signal transduction
GO:0030018 ISS Z disc
GO:0030552 IGI cAMP binding
GO:0030593 ISS neutrophil chemotaxis
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0035690 ISS cellular response to drug
GO:0044325 ISS ion channel binding
GO:0046872 IEA metal ion binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050852 IMP T cell receptor signaling pathway
GO:0050900 ISS leukocyte migration
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0071872 ISS cellular response to epinephrine stimulus
GO:0071944 IEA cell periphery
GO:0086004 ISS regulation of cardiac muscle cell contraction
GO:1901841 ISS regulation of high voltage-gated calcium channel activity
GO:1901898 ISS negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032868 pde4ba phosphodiesterase 4B, cAMP-specific a protein_coding Danio_rerio
ENSMUSG00000028525 Pde4b phosphodiesterase 4B, cAMP specific protein_coding Mus_musculus

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