C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphodiesterase 4B, cAMP-specific
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000341517 PDE4B-002 ENSG00000184588 9606 + 1:65793181-66373504 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastKidneyMuscleENST00000341517
Transcript ID Brain Breast Kidney Muscle
ENST00000341517 7.197±0.00 1.700±0.00 0.224±0.00 1.097±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002NS CIL_0002NS_0001 CGP 1:65792514-66748299

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001780 ISS neutrophil homeostasis
GO:0004114 ISS:IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005829 TAS cytosol
GO:0005891 ISS voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0007165 IEA signal transduction
GO:0030018 ISS Z disc
GO:0030552 IGI cAMP binding
GO:0030593 ISS neutrophil chemotaxis
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0035690 ISS cellular response to drug
GO:0044325 ISS ion channel binding
GO:0046872 IEA metal ion binding
GO:0050852 IMP T cell receptor signaling pathway
GO:0050900 ISS leukocyte migration
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0071872 ISS cellular response to epinephrine stimulus
GO:0086004 ISS regulation of cardiac muscle cell contraction
GO:1901841 ISS regulation of high voltage-gated calcium channel activity
GO:1901898 ISS negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000106911 Pde4b-003 protein_coding Mus_musculus 0 3103
ENSMUST00000106908 Pde4b-001 protein_coding Mus_musculus 0 2745
ENSMUST00000106904 Pde4b-006 protein_coding Mus_musculus 0 2612
ENSMUST00000097950 Pde4b-002 protein_coding Mus_musculus 0 2327
ENSMUST00000097949 Pde4b-005 protein_coding Mus_musculus 0 2183
ENSMUST00000030251 Pde4b-009 protein_coding Mus_musculus 0 2073
ENSMUST00000106901 Pde4b-004 protein_coding Mus_musculus 0 1480
ENSMUST00000173119 Pde4b-010 nonsense_mediated_decay Mus_musculus 0 599
ENSMUST00000172845 Pde4b-008 retained_intron Mus_musculus 0 366

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