C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 4B, cAMP specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028525 Pde4b 10090 + 4:102087543-102607259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030251 Pde4b-009 102587558-102605703 protein_coding
  ENSMUST00000097949 Pde4b-005 102589723-102605861 protein_coding
  ENSMUST00000097950 Pde4b-002 102570095-102605847 protein_coding
  ENSMUST00000106901 Pde4b-004 102589843-102603441 protein_coding
  ENSMUST00000106904 Pde4b-006 102421518-102605536 protein_coding
  ENSMUST00000106907 Pde4b-012 102254742-102555924 protein_coding
  ENSMUST00000106908 Pde4b-001 102255003-102607259 protein_coding
  ENSMUST00000106911 Pde4b-003 102087543-102605833 protein_coding
  ENSMUST00000133632 Pde4b-007 102470397-102488046 retained_intron
  ENSMUST00000172616 Pde4b-011 102430047-102542510 protein_coding
  ENSMUST00000172845 Pde4b-008 102087725-102195136 retained_intron
  ENSMUST00000173119 Pde4b-010 102087741-102557597 nonsense_mediated_decay
  ENSMUST00000174186 Pde4b-014 102255230-102506038 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030251ENSMUST00000097950ENSMUST00000106908
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030251 0.899±0.28 0.633±0.00 N/A N/A 3.094±0.00 1.124±0.18 N/A N/A 0.496±0.00 N/A N/A 0.958±0.18 N/A 1.214±0.43
ENSMUST00000097950 2.020±0.00 N/A 5.620±1.55 N/A N/A 0.975±0.00 1.558±0.00 N/A 0.490±0.05 3.058±0.96 4.700±1.35 1.378±0.35 0.874±0.00 N/A
ENSMUST00000106908 4.802±0.00 0.223±0.02 10.866±2.70 9.238±0.28 N/A 1.011±0.29 7.578±0.89 0.554±0.00 0.958±0.12 12.365±0.82 13.802±2.24 0.270±0.00 0.366±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002NS CIL_0002NS_0002 CGP 4:102087543-102973628

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001780 IMP neutrophil homeostasis
GO:0004114 IDA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 ISS 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005891 IDA voltage-gated calcium channel complex
GO:0006198 IDA cAMP catabolic process
GO:0007165 IEA signal transduction
GO:0008152 IEA metabolic process
GO:0030018 IMP Z disc
GO:0030552 IEA cAMP binding
GO:0030593 IMP neutrophil chemotaxis
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032743 IEA positive regulation of interleukin-2 production
GO:0035690 IDA cellular response to drug
GO:0044325 IPI ion channel binding
GO:0046872 IEA metal ion binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050852 IEA T cell receptor signaling pathway
GO:0050900 IMP leukocyte migration
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0071872 IMP cellular response to epinephrine stimulus
GO:0071944 IDA cell periphery
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:1901841 IMP regulation of high voltage-gated calcium channel activity
GO:1901898 IMP negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032868 pde4ba phosphodiesterase 4B, cAMP-specific a protein_coding Danio_rerio
ENSG00000184588 PDE4B phosphodiesterase 4B, cAMP-specific protein_coding Homo_sapiens

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