C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphodiesterase 4B, cAMP-specific
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000371045 PDE4B-007 ENSG00000184588 9606 + 1:66332004-66374579 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371045
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371045 2.959±0.00 1.894±0.00 4.267±1.62 2.360±0.12 1.105±0.10 0.426±0.07 0.202±0.03 0.938±0.78 6.868±0.64 1.409±0.67 0.839±0.29 1.326±0.27 1.020±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002NS CIL_0002NS_0001 CGP 1:65792514-66748299

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001780 ISS neutrophil homeostasis
GO:0004114 ISS:IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005829 TAS cytosol
GO:0005891 ISS voltage-gated calcium channel complex
GO:0006198 IEA cAMP catabolic process
GO:0007165 IEA signal transduction
GO:0030018 ISS Z disc
GO:0030552 IGI cAMP binding
GO:0030593 ISS neutrophil chemotaxis
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032743 IMP positive regulation of interleukin-2 production
GO:0035690 ISS cellular response to drug
GO:0044325 ISS ion channel binding
GO:0046872 IEA metal ion binding
GO:0050852 IMP T cell receptor signaling pathway
GO:0050900 ISS leukocyte migration
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0071872 ISS cellular response to epinephrine stimulus
GO:0086004 ISS regulation of cardiac muscle cell contraction
GO:1901841 ISS regulation of high voltage-gated calcium channel activity
GO:1901898 ISS negative regulation of relaxation of cardiac muscle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000097950 Pde4b-002 protein_coding Mus_musculus 0 2612
ENSMUST00000106908 Pde4b-001 protein_coding Mus_musculus 0 2333
ENSMUST00000106911 Pde4b-003 protein_coding Mus_musculus 0 2329
ENSMUST00000106904 Pde4b-006 protein_coding Mus_musculus 0 2198
ENSMUST00000097949 Pde4b-005 protein_coding Mus_musculus 0 2183
ENSMUST00000030251 Pde4b-009 protein_coding Mus_musculus 0 2073
ENSMUST00000106901 Pde4b-004 protein_coding Mus_musculus 0 1480

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