C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: roundabout, axon guidance receptor, homolog 2 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185008 ROBO2 9606 + 3:75906695-77649964 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332191 ROBO2-003 77040730-77647116 protein_coding
  ENST00000461745 ROBO2-002 77039886-77649964 protein_coding
  ENST00000469233 ROBO2-011 77603744-77617837 processed_transcript
  ENST00000470802 ROBO2-005 77629122-77649500 retained_intron
  ENST00000471893 ROBO2-010 77596674-77607954 protein_coding
  ENST00000473767 ROBO2-006 77040730-77647116 nonsense_mediated_decay
  ENST00000475034 ROBO2-007 76311096-77098213 processed_transcript
  ENST00000475334 ROBO2-012 77617726-77646119 protein_coding
  ENST00000487694 ROBO2-013 75906695-77647510 protein_coding
  ENST00000490534 ROBO2-008 77634925-77646265 protein_coding
  ENST00000490991 ROBO2-004 77588781-77618180 protein_coding
  ENST00000602589 ROBO2-001 75906802-77607811 protein_coding
  ENST00000614793 ROBO2-201 77477410-77649964 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000332191ENST00000461745ENST00000469233ENST00000470802ENST00000473767ENST00000475034ENST00000487694ENST00000490534ENST00000602589ENST00000614793
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000332191 N/A N/A N/A N/A N/A 0.100±0.00 0.008±0.00 0.258±0.00 0.005±0.00 N/A N/A 0.504±0.34 0.343±0.00 0.212±0.06
ENST00000461745 N/A 0.030±0.00 N/A 1.702±0.00 N/A N/A 0.015±0.00 N/A N/A 0.922±0.00 N/A 0.192±0.05 N/A 0.139±0.00
ENST00000469233 N/A N/A N/A N/A N/A N/A N/A 1.147±0.00 N/A N/A N/A N/A N/A N/A
ENST00000470802 0.010±0.00 0.007±0.00 N/A N/A N/A N/A 0.010±0.01 N/A 0.047±0.00 0.611±0.00 N/A N/A N/A N/A
ENST00000473767 N/A N/A 0.248±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.366±0.00 0.390±0.00 0.260±0.00
ENST00000475034 N/A N/A N/A N/A N/A N/A N/A 1.064±0.00 2.133±0.00 N/A N/A N/A N/A N/A
ENST00000487694 0.042±0.00 0.041±0.00 N/A 1.692±0.00 0.048±0.00 N/A N/A N/A 0.014±0.00 2.618±0.00 N/A 0.593±0.36 0.526±0.08 0.396±0.00
ENST00000490534 N/A N/A N/A N/A N/A N/A 0.066±0.00 N/A N/A N/A N/A N/A N/A 1.002±0.00
ENST00000602589 N/A N/A 0.290±0.00 5.525±0.00 0.134±0.00 N/A N/A N/A N/A N/A N/A 1.218±0.00 N/A N/A
ENST00000614793 N/A N/A N/A 2.041±0.00 0.031±0.00 0.167±0.00 N/A N/A 0.007±0.00 N/A 0.031±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 ISS metanephros development
GO:0001657 IMP ureteric bud development
GO:0005515 IEA protein binding
GO:0007155 IEA cell adhesion
GO:0007156 IDA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007411 ISS axon guidance
GO:0007417 NAS central nervous system development
GO:0007420 IEP brain development
GO:0008046 ISS axon guidance receptor activity
GO:0009986 IDA cell surface
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016199 ISS axon midline choice point recognition
GO:0021891 ISS olfactory bulb interneuron development
GO:0030673 ISS axolemma
GO:0031290 ISS retinal ganglion cell axon guidance
GO:0032870 IEP cellular response to hormone stimulus
GO:0042802 IDA identical protein binding
GO:0050772 IDA positive regulation of axonogenesis
GO:0050925 IDA negative regulation of negative chemotaxis
GO:0051964 ISS negative regulation of synapse assembly
GO:0061364 IEP apoptotic process involved in luteolysis
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014891 robo2 roundabout homolog 2 protein_coding Danio_rerio
ENSDARG00000078366 robo2 roundabout homolog 2 protein_coding Danio_rerio
ENSMUSG00000052516 Robo2 roundabout homolog 2 (Drosophila) protein_coding Mus_musculus

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