C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interferon regulatory factor 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185507 IRF7 9606 - 11:612553-615999 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000330243 IRF7-001 612591-615970 protein_coding
  ENST00000348655 IRF7-005 612555-615650 protein_coding
  ENST00000397566 IRF7-201 612555-615728 protein_coding
  ENST00000397570 IRF7-202 612576-615728 protein_coding
  ENST00000397574 IRF7-002 612559-615999 protein_coding
  ENST00000469048 IRF7-004 612583-615650 nonsense_mediated_decay
  ENST00000525445 IRF7-006 612553-615626 protein_coding
  ENST00000525750 IRF7-009 613553-614397 retained_intron
  ENST00000527160 IRF7-010 614009-614887 retained_intron
  ENST00000528413 IRF7-014 612583-613854 retained_intron
  ENST00000531912 IRF7-013 612588-613591 retained_intron
  ENST00000532096 IRF7-011 614090-615650 retained_intron
  ENST00000532326 IRF7-012 612591-615983 nonsense_mediated_decay
  ENST00000532788 IRF7-008 613822-615979 nonsense_mediated_decay
  ENST00000533182 IRF7-007 612561-615950 nonsense_mediated_decay
  ENST00000533190 IRF7-015 614783-615938 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000330243ENST00000348655ENST00000397566ENST00000397570ENST00000397574ENST00000469048ENST00000525445ENST00000527160ENST00000528413ENST00000531912ENST00000532096ENST00000532326ENST00000532788ENST00000533182ENST00000533190
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000330243 N/A N/A N/A 0.453±0.00 N/A N/A 0.551±0.00 N/A N/A N/A 2.422±0.00 3.332±0.00 2.930±2.04 N/A
ENST00000348655 N/A N/A N/A N/A N/A N/A N/A 2.041±0.00 N/A 0.472±0.00 0.989±0.00 1.307±0.17 N/A N/A
ENST00000397566 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.393±0.00 N/A
ENST00000397570 N/A N/A N/A N/A 0.895±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000397574 1.253±0.00 N/A N/A N/A N/A 1.460±0.00 N/A N/A N/A 10.577±0.00 N/A 3.828±2.14 1.636±0.92 N/A
ENST00000469048 N/A N/A N/A N/A N/A N/A N/A 2.297±0.00 N/A N/A N/A 2.831±0.18 5.541±0.00 N/A
ENST00000525445 N/A 4.631±0.00 N/A N/A 1.546±0.00 N/A N/A 4.770±0.00 8.667±0.00 9.429±0.00 N/A 5.085±0.00 N/A 3.142±0.00
ENST00000527160 N/A N/A N/A N/A N/A N/A N/A 1.489±0.00 N/A N/A N/A N/A N/A N/A
ENST00000528413 N/A N/A N/A 0.593±0.00 N/A N/A 1.249±0.57 N/A 0.138±0.00 0.745±0.00 2.406±0.24 1.641±0.00 5.435±0.00 N/A
ENST00000531912 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.495±0.00 N/A 2.954±0.00 N/A 0.871±0.00
ENST00000532096 N/A N/A 0.482±0.00 0.494±0.00 0.907±0.00 0.981±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000532326 N/A N/A N/A N/A N/A N/A N/A 3.639±0.00 6.351±0.00 N/A N/A N/A 2.387±0.00 N/A
ENST00000532788 N/A N/A N/A N/A 2.966±0.00 1.916±0.00 1.120±0.00 N/A N/A N/A N/A N/A N/A 3.682±0.00
ENST00000533182 N/A 3.886±0.00 N/A 0.534±0.00 N/A 1.836±0.00 0.076±0.00 N/A N/A 8.365±0.00 N/A N/A 2.410±0.00 N/A
ENST00000533190 N/A N/A N/A 0.164±0.00 0.804±0.00 0.766±0.00 0.184±0.00 0.396±0.00 0.532±0.00 N/A N/A 0.215±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006RQ CIL_0006RQ_0002 CGP 11:576486-615999
CIL_0003OO CIL_0003OO_0001 CGP 11:612553-626078

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000975 IEA regulatory region DNA binding
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0002819 IDA regulation of adaptive immune response
GO:0003677 IMP DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006974 TAS cellular response to DNA damage stimulus
GO:0009615 TAS response to virus
GO:0010008 TAS endosome membrane
GO:0016064 IEA immunoglobulin mediated immune response
GO:0019043 TAS establishment of viral latency
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0032479 TAS regulation of type I interferon production
GO:0032481 TAS positive regulation of type I interferon production
GO:0032607 ISS interferon-alpha production
GO:0032608 ISS interferon-beta production
GO:0032727 IDA positive regulation of interferon-alpha production
GO:0032728 TAS positive regulation of interferon-beta production
GO:0034124 ISS regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127 ISS regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0039530 TAS MDA-5 signaling pathway
GO:0045087 TAS innate immune response
GO:0045351 IEA type I interferon biosynthetic process
GO:0045655 TAS regulation of monocyte differentiation
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050776 TAS regulation of immune response
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0060340 IEA positive regulation of type I interferon-mediated signaling pathway
GO:2000110 TAS negative regulation of macrophage apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045661 irf7 interferon regulatory factor 7 protein_coding Danio_rerio
ENSMUSG00000025498 Irf7 interferon regulatory factor 7 protein_coding Mus_musculus

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