C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin receptor substrate 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185950 IRS2 9606 - 13:109752698-109786568 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000375856 IRS2-001 109752698-109786568 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375856
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375856 27.605±0.00 1.299±0.00 0.948±0.00 10.820±7.99 11.513±6.81 6.676±6.15 7.831±7.38 3.088±0.41 3.513±2.41 2.664±2.07 9.997±8.12 5.145±2.11 10.989±3.80 2.980±2.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010K CIL_00010K_0001 CGP 13:108596152-109786568
CIL_00077O CIL_00077O_0001 CGP 13:109752698-110307149

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002903 ISS negative regulation of B cell apoptotic process
GO:0004871 IEA signal transducer activity
GO:0005158 IEA insulin receptor binding
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006006 TAS glucose metabolic process
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007420 IEA brain development
GO:0008283 IEA cell proliferation
GO:0008284 NAS positive regulation of cell proliferation
GO:0008286 ISS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009749 ISS response to glucose
GO:0010748 IMP negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907 IMP positive regulation of glucose metabolic process
GO:0019216 TAS regulation of lipid metabolic process
GO:0019901 IEA protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0019904 IEA protein domain specific binding
GO:0030335 IEA positive regulation of cell migration
GO:0030879 IEA mammary gland development
GO:0030890 ISS positive regulation of B cell proliferation
GO:0032000 IMP positive regulation of fatty acid beta-oxidation
GO:0032024 ISS positive regulation of insulin secretion
GO:0032869 IMP cellular response to insulin stimulus
GO:0033673 ISS negative regulation of kinase activity
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0045087 TAS innate immune response
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0046326 IMP positive regulation of glucose import
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0055088 TAS lipid homeostasis
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0071333 IEA cellular response to glucose stimulus
GO:0071889 IEA 14-3-3 protein binding
GO:1901653 IEA cellular response to peptide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037099 IRS2 insulin receptor substrate 2 protein_coding Danio_rerio
ENSMUSG00000038894 Irs2 insulin receptor substrate 2 protein_coding Mus_musculus

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