C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin receptor substrate 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000038894 Irs2 10090 - 8:10986980-11008458 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000040514 Irs2-201 10986980-11008458 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000040514
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000040514 0.537±0.04 6.686±2.14 1.933±0.15 5.621±3.55 7.024±3.17 1.502±0.28 2.761±1.70 1.319±0.71 6.143±1.35 2.245±0.17 5.717±1.92 11.399±6.65 0.676±0.45

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010K CIL_00010K_0002 CGP 8:10272572-11008458
CIL_00077O CIL_00077O_0002 CGP 8:10986980-11312826

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002053 IGI positive regulation of mesenchymal cell proliferation
GO:0002903 IMP negative regulation of B cell apoptotic process
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0007420 IMP brain development
GO:0008283 IMP cell proliferation
GO:0008284 IGI positive regulation of cell proliferation
GO:0008286 IMP insulin receptor signaling pathway
GO:0009749 IDA response to glucose
GO:0010748 IEA negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907 IEA positive regulation of glucose metabolic process
GO:0019901 IDA protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0019904 IEA protein domain specific binding
GO:0030335 IGI positive regulation of cell migration
GO:0030879 IGI mammary gland development
GO:0030890 IDA positive regulation of B cell proliferation
GO:0032000 IEA positive regulation of fatty acid beta-oxidation
GO:0032024 IMP positive regulation of insulin secretion
GO:0032869 IDA cellular response to insulin stimulus
GO:0033673 IMP negative regulation of kinase activity
GO:0043548 IDA phosphatidylinositol 3-kinase binding
GO:0045725 IEA positive regulation of glycogen biosynthetic process
GO:0046326 IEA positive regulation of glucose import
GO:0071333 IEA cellular response to glucose stimulus
GO:0071889 IEA 14-3-3 protein binding
GO:1901653 IEA cellular response to peptide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037099 IRS2 insulin receptor substrate 2 protein_coding Danio_rerio
ENSG00000185950 IRS2 insulin receptor substrate 2 protein_coding Homo_sapiens

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