C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: breakpoint cluster region
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186716 BCR 9606 + 22:23179704-23318037 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000305877 BCR-001 23180210-23318037 protein_coding
  ENST00000359540 BCR-002 23180365-23315950 protein_coding
  ENST00000398512 BCR-201 23180961-23318037 protein_coding
  ENST00000419722 BCR-016 23289615-23310433 processed_transcript
  ENST00000427791 BCR-006 23253960-23285114 protein_coding
  ENST00000436990 BCR-005 23309474-23318034 processed_transcript
  ENST00000458056 BCR-020 23312388-23314695 processed_transcript
  ENST00000463770 BCR-004 23198253-23253833 processed_transcript
  ENST00000466076 BCR-015 23283788-23287173 retained_intron
  ENST00000471452 BCR-017 23295041-23302863 processed_transcript
  ENST00000475025 BCR-019 23306745-23313999 processed_transcript
  ENST00000478978 BCR-018 23306154-23310433 processed_transcript
  ENST00000479188 BCR-013 23179704-23261428 processed_transcript
  ENST00000480973 BCR-014 23251032-23261393 processed_transcript
  ENST00000487679 BCR-003 23198332-23253833 processed_transcript
  ENST00000487968 BCR-012 23283209-23291131 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000305877ENST00000359540ENST00000398512ENST00000419722ENST00000427791ENST00000436990ENST00000466076
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000305877 2.648±0.00 N/A N/A 4.262±0.49 N/A 1.713±0.00 0.689±0.40 N/A 1.564±0.00 2.011±0.00 N/A 2.739±1.22 2.504±0.00 8.862±0.00
ENST00000359540 11.796±0.00 16.213±0.00 1.421±0.00 16.663±0.00 19.399±0.00 4.950±4.35 6.351±0.00 10.368±8.81 8.984±0.00 24.542±0.00 0.610±0.36 8.782±3.49 12.614±1.35 9.582±0.00
ENST00000398512 1.933±0.00 N/A N/A 2.930±0.00 N/A 1.374±0.00 0.849±0.00 N/A 1.180±0.00 4.563±0.00 0.310±0.12 5.252±0.63 3.035±0.77 3.054±0.00
ENST00000419722 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 16.250±0.00 12.588±0.00
ENST00000427791 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 14.462±0.00 N/A
ENST00000436990 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.134±0.00
ENST00000466076 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.110±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002X0 CIL_0002X0_0001 CGP 22:23145326-23318037

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 TAS protein tyrosine kinase activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 TAS:IEA GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005622 IEA intracellular
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0007165 TAS:IEA signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007420 IEA brain development
GO:0016020 IDA membrane
GO:0016301 TAS kinase activity
GO:0018108 TAS peptidyl-tyrosine phosphorylation
GO:0019899 IEA enzyme binding
GO:0030036 IEA actin cytoskeleton organization
GO:0030336 IEA negative regulation of cell migration
GO:0030675 IEA Rac GTPase activator activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032496 IEA response to lipopolysaccharide
GO:0032855 IEA positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042472 IEA inner ear morphogenesis
GO:0043234 IDA protein complex
GO:0043314 IEA negative regulation of neutrophil degranulation
GO:0046777 IEA protein autophosphorylation
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0050728 IEA negative regulation of inflammatory response
GO:0050766 IEA positive regulation of phagocytosis
GO:0050885 IEA neuromuscular process controlling balance
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051726 IEA regulation of cell cycle
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042329 BCR (1 of 2) breakpoint cluster region protein_coding Danio_rerio
ENSDARG00000079286 bcr breakpoint cluster region protein_coding Danio_rerio
ENSMUSG00000009681 Bcr breakpoint cluster region protein_coding Mus_musculus

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