C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: two pore segment channel 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186815 TPCN1 9606 + 12:113221050-113298585 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000335509 TPCN1-001 113221438-113298585 protein_coding
  ENST00000392569 TPCN1-003 113244261-113296194 protein_coding
  ENST00000428632 TPCN1-004 113244503-113288695 retained_intron
  ENST00000541517 TPCN1-201 113225246-113298582 protein_coding
  ENST00000546503 TPCN1-012 113277253-113280314 retained_intron
  ENST00000546781 TPCN1-011 113276918-113287065 protein_coding
  ENST00000546787 TPCN1-007 113293019-113296012 processed_transcript
  ENST00000546907 TPCN1-008 113290049-113291931 retained_intron
  ENST00000547275 TPCN1-015 113221074-113266218 protein_coding
  ENST00000547955 TPCN1-009 113284716-113291623 nonsense_mediated_decay
  ENST00000548465 TPCN1-013 113260302-113268852 protein_coding
  ENST00000549279 TPCN1-014 113221464-113260402 protein_coding
  ENST00000550543 TPCN1-010 113284625-113287404 retained_intron
  ENST00000550785 TPCN1-002 113221460-113298585 protein_coding
  ENST00000550873 TPCN1-018 113221232-113266197 protein_coding
  ENST00000551096 TPCN1-019 113221429-113260412 protein_coding
  ENST00000551099 TPCN1-020 113221438-113260402 protein_coding
  ENST00000551127 TPCN1-006 113277003-113296128 retained_intron
  ENST00000552077 TPCN1-005 113221486-113296129 retained_intron
  ENST00000552542 TPCN1-022 113244368-113268777 protein_coding
  ENST00000552642 TPCN1-017 113221050-113267879 protein_coding
  ENST00000552897 TPCN1-021 113221446-113267955 protein_coding
  ENST00000552985 TPCN1-016 113221080-113266329 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000335509ENST00000392569ENST00000541517ENST00000546787ENST00000550785ENST00000551127
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000335509 4.753±0.00 3.001±0.00 N/A 3.226±1.94 5.847±0.00 5.083±0.00 8.594±7.35 5.082±0.00 4.509±0.00 2.643±0.00 1.902±0.00 6.167±2.57 7.626±0.15 11.638±0.00
ENST00000392569 N/A N/A N/A N/A 1.475±0.00 N/A 1.647±0.00 1.931±0.00 N/A 2.939±0.00 1.686±0.00 1.452±0.00 N/A N/A
ENST00000541517 3.950±0.00 N/A N/A 0.708±0.00 2.514±0.00 N/A 2.777±1.38 0.264±0.00 N/A 2.465±0.00 3.151±2.32 12.997±0.00 3.539±0.00 N/A
ENST00000546787 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 65.762±0.00 24.070±0.00 N/A
ENST00000550785 N/A N/A N/A N/A 0.976±0.00 1.919±0.00 N/A N/A 0.876±0.00 N/A N/A 1.669±1.18 1.908±0.00 3.469±0.00
ENST00000551127 N/A N/A 2.050±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078D CIL_00078D_0002 CGP 12:113195441-113298585

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005216 IEA ion channel activity
GO:0005245 IEA:IBA voltage-gated calcium channel activity
GO:0005515 IPI protein binding
GO:0005765 IDA lysosomal membrane
GO:0005886 IBA plasma membrane
GO:0006811 IEA ion transport
GO:0006816 IBA calcium ion transport
GO:0010008 IDA endosome membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0034220 IBA ion transmembrane transport
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042802 IPI identical protein binding
GO:0055085 TAS:IEA transmembrane transport
GO:0070588 IEA calcium ion transmembrane transport
GO:0072345 IDA NAADP-sensitive calcium-release channel activity
GO:0086010 IBA membrane depolarization during action potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062362 tpcn1 two pore segment channel 1 protein_coding Danio_rerio
ENSMUSG00000032741 Tpcn1 two pore channel 1 protein_coding Mus_musculus

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