C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DCC netrin 1 receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000187323 DCC 9606 + 18:52340172-53535903 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000304775 DCC-002 52752162-53416557 nonsense_mediated_decay
  ENST00000412726 DCC-201 52752032-53535903 protein_coding
  ENST00000442544 DCC-001 52340172-53535899 protein_coding
  ENST00000577224 DCC-017 53530297-53530451 processed_transcript
  ENST00000578080 DCC-004 52752060-52759092 protein_coding
  ENST00000578949 DCC-012 52934803-53157435 protein_coding
  ENST00000579349 DCC-009 52752166-52906286 nonsense_mediated_decay
  ENST00000579666 DCC-005 52752174-52757281 processed_transcript
  ENST00000579702 DCC-016 53499315-53526948 retained_intron
  ENST00000579883 DCC-014 52923799-53063613 retained_intron
  ENST00000579941 DCC-015 53391784-53416441 protein_coding
  ENST00000580024 DCC-010 52752159-52906267 processed_transcript
  ENST00000580146 DCC-013 52940929-53157406 processed_transcript
  ENST00000581559 DCC-003 52752167-52906256 nonsense_mediated_decay
  ENST00000581580 DCC-011 52934772-53530592 protein_coding
  ENST00000582595 DCC-006 52752230-52754256 processed_transcript
  ENST00000582875 DCC-007 52752161-52816889 protein_coding
  ENST00000584710 DCC-008 52923784-52931950 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000304775ENST00000412726ENST00000442544ENST00000578949ENST00000579349ENST00000580024ENST00000581580
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000304775 N/A N/A N/A N/A N/A N/A 0.008±0.00 N/A N/A N/A N/A N/A 3.008±1.58
ENST00000412726 N/A 0.065±0.00 N/A N/A 0.027±0.00 N/A 0.007±0.00 0.018±0.01 0.190±0.04 N/A 0.003±0.00 N/A 0.425±0.11
ENST00000442544 0.005±0.00 N/A N/A 0.455±0.00 N/A N/A N/A N/A N/A N/A 0.029±0.00 N/A N/A
ENST00000578949 N/A N/A N/A N/A N/A 0.251±0.00 N/A N/A 1.996±0.00 N/A N/A N/A N/A
ENST00000579349 N/A N/A 0.464±0.00 N/A 0.640±0.00 N/A N/A 0.419±0.00 N/A N/A N/A 0.060±0.00 N/A
ENST00000580024 N/A N/A N/A N/A 0.074±0.00 N/A 0.091±0.00 N/A N/A N/A N/A N/A N/A
ENST00000581580 N/A N/A N/A 0.400±0.00 N/A N/A N/A N/A 0.378±0.00 0.025±0.00 0.033±0.00 N/A 1.945±0.34

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008ER CIL_0008ER_0001 VISTA 18:51746215-52348141

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001764 IEA neuron migration
GO:0001975 IEA response to amphetamine
GO:0003713 IEA transcription coactivator activity
GO:0004888 TAS transmembrane signaling receptor activity
GO:0005042 IEA netrin receptor activity
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006915 TAS apoptotic process
GO:0007409 TAS axonogenesis
GO:0007411 TAS axon guidance
GO:0010976 IEA positive regulation of neuron projection development
GO:0010977 TAS negative regulation of neuron projection development
GO:0016021 IEA integral component of membrane
GO:0021965 IEA spinal cord ventral commissure morphogenesis
GO:0030424 IEA axon
GO:0032584 IEA growth cone membrane
GO:0033563 IEA dorsal/ventral axon guidance
GO:0033564 IEA anterior/posterior axon guidance
GO:0038007 IEA netrin-activated signaling pathway
GO:0042802 IEA identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043065 TAS positive regulation of apoptotic process
GO:0045121 IEA membrane raft
GO:0048671 TAS negative regulation of collateral sprouting
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:1901214 IMP regulation of neuron death
GO:2000171 TAS negative regulation of dendrite development
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087980 CABZ01100973.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000090360 DCC (2 of 2) DCC netrin 1 receptor protein_coding Danio_rerio
ENSMUSG00000060534 Dcc deleted in colorectal carcinoma protein_coding Mus_musculus

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